FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036701335> ?p ?o ?g. }

• W2036701335 endingPage "85" @default.
• W2036701335 startingPage "278" @default.
• W2036701335 abstract "Synthetic metalloporphyrin derivatives of heme have been identified as competitive inhibitors of heme oxygenase, the rate-limiting enzyme in the heme degradation pathway that produces equimolar quantities of carbon monoxide, biliverdin, and bilirubin. Therefore, administration of metalloporphyrin has been proposed as one means to prevent excessive hyperbilirubinemia in human neonates. Tin proto- and meso-porphyrin have been studied for the suppression of neonatal jaundice. However, these compounds are also photosensitizers. This property may limit the clinical use of these compounds, particularly in infants being exposed simultaneously to phototherapy. Via measurements of carbon monoxide, we have studied the photooxidative, metabolic, and inhibitory characteristics of metalloporphyrins that have not yet been studied for this purpose: deuteroporphyrin bisglycol (DBG), iron deuteroporphyrin bisglycol (FeBG), tin deuteroporphyrin bisglycol (SnBG),tin deuteroporphyrin (SnDP), chromium deuteroporphyrin (CrDP), and zinc deuteroporphyrin (ZnDP). Of the six compounds, SnDP, SnBG, and DBG were significantly photoreactive in vitro. Furthermore, in vitro measurements of brain, liver, and spleen heme oxygenase activity inhibition indicated that, of the nonphotoreactive compounds, CrDP and ZnDP were the most potent inhibitors. Only FeBG served as a substrate for the heme oxygenase reaction. The concentration for 50% inhibition with the three tissues ranged from 0.6 to 1.3 microM for CrDP and from 11.0 to 13.5 microM for ZnDP. When 25 mumol CrDP and 50 mumol ZnDP per kilogram body weight were administered to rats given a heme load of 30 mumol/kg body weight, the total body carbon monoxide excretion due to the administered heme load was reduced by 46 and 32%, respectively, at t = 7.5 h, when the experiment was terminated in order to measure heme oxygenase activity. Brain heme oxygenase activity was not affected by the metalloporphyrin treatment. However, both CrDP and ZnDP inhibited liver tissue heme oxygenase activity to 5 and 20%, respectively, whereas only CrDP inhibited spleen tissue heme oxygenase, to 7% of untreated control. Thus, CrDP appears to be the most attractive of the six compounds and deserves further study." @default.
• W2036701335 created "2016-06-24" @default.
• W2036701335 creator A5004500107 @default.
• W2036701335 creator A5055733234 @default.
• W2036701335 creator A5083486839 @default.
• W2036701335 date "1996-03-01" @default.
• W2036701335 modified "2023-09-27" @default.
• W2036701335 title "Characterization of porphyrin heme oxygenase inhibitors." @default.
• W2036701335 cites W1529948332 @default.
• W2036701335 cites W1584222263 @default.
• W2036701335 cites W1586487499 @default.
• W2036701335 cites W1591048367 @default.
• W2036701335 cites W1656167931 @default.
• W2036701335 cites W1775749144 @default.
• W2036701335 cites W1828218942 @default.
• W2036701335 cites W1862659461 @default.
• W2036701335 cites W1930020594 @default.
• W2036701335 cites W1965187409 @default.
• W2036701335 cites W1965921918 @default.
• W2036701335 cites W1966018140 @default.
• W2036701335 cites W1966074962 @default.
• W2036701335 cites W1966582616 @default.
• W2036701335 cites W1976866228 @default.
• W2036701335 cites W1981165639 @default.
• W2036701335 cites W1981407745 @default.
• W2036701335 cites W1985082039 @default.
• W2036701335 cites W1986853072 @default.
• W2036701335 cites W2011019337 @default.
• W2036701335 cites W2021783250 @default.
• W2036701335 cites W2034542103 @default.
• W2036701335 cites W2041742409 @default.
• W2036701335 cites W2044288756 @default.
• W2036701335 cites W2047850165 @default.
• W2036701335 cites W2054802842 @default.
• W2036701335 cites W2058908110 @default.
• W2036701335 cites W2059889329 @default.
• W2036701335 cites W2062188620 @default.
• W2036701335 cites W2067040292 @default.
• W2036701335 cites W2077574201 @default.
• W2036701335 cites W2084589715 @default.
• W2036701335 cites W2087516645 @default.
• W2036701335 cites W2117573289 @default.
• W2036701335 cites W2118980484 @default.
• W2036701335 cites W2119781983 @default.
• W2036701335 cites W2122779395 @default.
• W2036701335 cites W2124433916 @default.
• W2036701335 cites W2135880290 @default.
• W2036701335 cites W2156911455 @default.
• W2036701335 cites W2396631465 @default.
• W2036701335 cites W2409486247 @default.
• W2036701335 cites W2441622066 @default.
• W2036701335 cites W2474321416 @default.
• W2036701335 cites W3012578252 @default.
• W2036701335 cites W637538192 @default.
• W2036701335 cites W2244006724 @default.
• W2036701335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8773407" @default.
• W2036701335 hasPublicationYear "1996" @default.
• W2036701335 type Work @default.
• W2036701335 sameAs 2036701335 @default.
• W2036701335 citedByCount "17" @default.
• W2036701335 countsByYear W20367013352012 @default.
• W2036701335 countsByYear W20367013352015 @default.
• W2036701335 countsByYear W20367013352020 @default.
• W2036701335 countsByYear W20367013352021 @default.
• W2036701335 countsByYear W20367013352022 @default.
• W2036701335 crossrefType "journal-article" @default.
• W2036701335 hasAuthorship W2036701335A5004500107 @default.
• W2036701335 hasAuthorship W2036701335A5055733234 @default.
• W2036701335 hasAuthorship W2036701335A5083486839 @default.
• W2036701335 hasConcept C134018914 @default.
• W2036701335 hasConcept C161790260 @default.
• W2036701335 hasConcept C181199279 @default.
• W2036701335 hasConcept C185592680 @default.
• W2036701335 hasConcept C2776217839 @default.
• W2036701335 hasConcept C2776253728 @default.
• W2036701335 hasConcept C2777513400 @default.
• W2036701335 hasConcept C2779219270 @default.
• W2036701335 hasConcept C2779480358 @default.
• W2036701335 hasConcept C512735826 @default.
• W2036701335 hasConcept C55493867 @default.
• W2036701335 hasConcept C86803240 @default.
• W2036701335 hasConceptScore W2036701335C134018914 @default.
• W2036701335 hasConceptScore W2036701335C161790260 @default.
• W2036701335 hasConceptScore W2036701335C181199279 @default.
• W2036701335 hasConceptScore W2036701335C185592680 @default.
• W2036701335 hasConceptScore W2036701335C2776217839 @default.
• W2036701335 hasConceptScore W2036701335C2776253728 @default.
• W2036701335 hasConceptScore W2036701335C2777513400 @default.
• W2036701335 hasConceptScore W2036701335C2779219270 @default.
• W2036701335 hasConceptScore W2036701335C2779480358 @default.
• W2036701335 hasConceptScore W2036701335C512735826 @default.
• W2036701335 hasConceptScore W2036701335C55493867 @default.
• W2036701335 hasConceptScore W2036701335C86803240 @default.
• W2036701335 hasIssue "3" @default.
• W2036701335 hasLocation W20367013351 @default.
• W2036701335 hasOpenAccess W2036701335 @default.
• W2036701335 hasPrimaryLocation W20367013351 @default.
• W2036701335 hasRelatedWork W1581584570 @default.

• next