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- W2036702368 abstract "Organic waste workers are exposed to high endotoxin levels that may result in respiratory health effects. This study describes changes in lung function and methacholine airway responsiveness over a workweek in household organic waste loaders.Assessment of lung function and methacholine airway responsiveness before and after a workweek in six organic waste loaders with and ten loaders without regular respiratory symptoms. Methacholine responsiveness was expressed as dose-response slope, i.e. % fall in FEV(1) per mg methacholine compared to either the post-saline value (DRS(sal)), or the highest FEV(1) (DRS(max)).Monday morning, FEV(1) was similar in cases and controls. Over the workweek, FEV(1) and MMEF decreased slightly in both cases and controls (P > 0.10). In contrast, DRS increased in cases and decreased in control subjects (P < 0.10). The difference in % change of DRS was statistically significant after adjustment for smoking and age.Our results suggest exaggeration of pre-existent airway inflammation during the workweek in organic waste loaders with regular respiratory symptoms. This needs confirmation in larger studies." @default.
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- W2036702368 date "2007-01-06" @default.
- W2036702368 modified "2023-10-16" @default.
- W2036702368 title "Change in airway responsiveness over a workweek in organic waste loaders" @default.
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- W2036702368 doi "https://doi.org/10.1007/s00420-006-0166-8" @default.
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