Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036702429> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2036702429 endingPage "345" @default.
- W2036702429 startingPage "342" @default.
- W2036702429 abstract "Recombinant human erythropoietin (rHuEpo) is an effective therapy for anaemia in most patients with end-stage renal disease (ESRD). However, there remain a minority of patients with ESRD who are resistant to the effects of rHuEpo. The present study examined the role of aluminium overload and hyperparathyroidism of the biological effects of rHuEpo. Twenty-two patients aged 26-74 (mean 53 +/- SD 15.5) received rHuEpo 50-200 U/kg per week for 16.5 +/- 8.0 months (range 3-27). Haemoglobin was maintained at 11.5-13.0 g/dl by appropriate dose adjustment. Iron supplements were provided to maintain serum ferritin greater than 200 ng/ml. The mean time to rHuEpo response (Hb greater than 2 g/dl over baseline) was 6.1 +/- 2.6 weeks. Mean pretreatment serum aluminium correlated with time to Hb response (r = 0.48; P less than 0.05) and pretreatment mean corpuscular volume (r = 0.43; P less than 0.05) but not with eventual rHuEpo maintenance dose. PTH did not correlate with either Hb response or eventual maintenance rHuEpo dose. In summary, elevated serum aluminium concentrations were associated with an initial resistance to the biological effects of rHuEpo but had no effect on long-term dose requirements. In contrast, no impact of PTH on either immediate or long-term rHuEpo dose was evident." @default.
- W2036702429 created "2016-06-24" @default.
- W2036702429 creator A5008149390 @default.
- W2036702429 creator A5025745639 @default.
- W2036702429 creator A5027138774 @default.
- W2036702429 creator A5082975078 @default.
- W2036702429 date "1991-01-01" @default.
- W2036702429 modified "2023-09-27" @default.
- W2036702429 title "The Role of Aluminium and Parathyroid Hormone in Erythropoietin Resistance in Haemodialysis Patients" @default.
- W2036702429 doi "https://doi.org/10.1093/ndt/6.5.342" @default.
- W2036702429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1870750" @default.
- W2036702429 hasPublicationYear "1991" @default.
- W2036702429 type Work @default.
- W2036702429 sameAs 2036702429 @default.
- W2036702429 citedByCount "23" @default.
- W2036702429 countsByYear W20367024292013 @default.
- W2036702429 countsByYear W20367024292018 @default.
- W2036702429 crossrefType "journal-article" @default.
- W2036702429 hasAuthorship W2036702429A5008149390 @default.
- W2036702429 hasAuthorship W2036702429A5025745639 @default.
- W2036702429 hasAuthorship W2036702429A5027138774 @default.
- W2036702429 hasAuthorship W2036702429A5082975078 @default.
- W2036702429 hasConcept C126322002 @default.
- W2036702429 hasConcept C126894567 @default.
- W2036702429 hasConcept C134018914 @default.
- W2036702429 hasConcept C2775945674 @default.
- W2036702429 hasConcept C2778063415 @default.
- W2036702429 hasConcept C2778248108 @default.
- W2036702429 hasConcept C2778319317 @default.
- W2036702429 hasConcept C2778534260 @default.
- W2036702429 hasConcept C2778838027 @default.
- W2036702429 hasConcept C2779703530 @default.
- W2036702429 hasConcept C2780959883 @default.
- W2036702429 hasConcept C2781058662 @default.
- W2036702429 hasConcept C2781208988 @default.
- W2036702429 hasConcept C519063684 @default.
- W2036702429 hasConcept C71924100 @default.
- W2036702429 hasConcept C90924648 @default.
- W2036702429 hasConceptScore W2036702429C126322002 @default.
- W2036702429 hasConceptScore W2036702429C126894567 @default.
- W2036702429 hasConceptScore W2036702429C134018914 @default.
- W2036702429 hasConceptScore W2036702429C2775945674 @default.
- W2036702429 hasConceptScore W2036702429C2778063415 @default.
- W2036702429 hasConceptScore W2036702429C2778248108 @default.
- W2036702429 hasConceptScore W2036702429C2778319317 @default.
- W2036702429 hasConceptScore W2036702429C2778534260 @default.
- W2036702429 hasConceptScore W2036702429C2778838027 @default.
- W2036702429 hasConceptScore W2036702429C2779703530 @default.
- W2036702429 hasConceptScore W2036702429C2780959883 @default.
- W2036702429 hasConceptScore W2036702429C2781058662 @default.
- W2036702429 hasConceptScore W2036702429C2781208988 @default.
- W2036702429 hasConceptScore W2036702429C519063684 @default.
- W2036702429 hasConceptScore W2036702429C71924100 @default.
- W2036702429 hasConceptScore W2036702429C90924648 @default.
- W2036702429 hasIssue "5" @default.
- W2036702429 hasLocation W20367024291 @default.
- W2036702429 hasLocation W20367024292 @default.
- W2036702429 hasOpenAccess W2036702429 @default.
- W2036702429 hasPrimaryLocation W20367024291 @default.
- W2036702429 hasRelatedWork W1969999796 @default.
- W2036702429 hasRelatedWork W2010782076 @default.
- W2036702429 hasRelatedWork W2013152947 @default.
- W2036702429 hasRelatedWork W2034966366 @default.
- W2036702429 hasRelatedWork W2058178602 @default.
- W2036702429 hasRelatedWork W2118925163 @default.
- W2036702429 hasRelatedWork W2156768159 @default.
- W2036702429 hasRelatedWork W4231348632 @default.
- W2036702429 hasRelatedWork W4255556714 @default.
- W2036702429 hasRelatedWork W50706836 @default.
- W2036702429 hasVolume "6" @default.
- W2036702429 isParatext "false" @default.
- W2036702429 isRetracted "false" @default.
- W2036702429 magId "2036702429" @default.
- W2036702429 workType "article" @default.