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• W2036704572 abstract "Metabolic syndrome (MS) is linked to cardiovascular risk. Adult Treatment Panel III (ATPIII) criteria provide a definition for diagnosis of MS. ATPIII defined non-optimal blood pressure (≥130/85mmHg) might provide effective partition to identify cardiac abnormalities in the presence of MS. Echocardiography was performed in 595 non-diabetic MS participants (31.5% men, 59±7.8 years) of the Strong Heart Study. Participants with the MS were divided according to the presence of non-optimal blood pressure (≥130/85mmHg). Comparison of quintiles of participants with non-optimal blood pressure was used to assess the effect of increasing values of blood pressure on cardiovascular structure and outcome. MS participants with non-optimal blood pressure (n= 369; 39% men) were older (61 vs 58 y, p<0.001), with no significant differences in body mass index, heart rate or fasting glucose compared to MS participants with normal blood pressure. After controlling for age and gender, non-optimal blood pressure was associated with higher left ventricular (LV) diameter, LV indexed mass (both p<0.001), as well as with higher relative wall thickness, reduced midwall shortening and prolonged mitral deceleration time (all p<0.05). In Cox regression analysis, controlling for age and gender, the presence of non-optimal blood pressure was independently associated with a higher rate of CV events (OR=1.58, 95%CI= 1.04 vs 2.42; p=0.039). Higher quintiles of blood pressure were associated with older age and higher body mass index (both p<0.01), with no significant differences in heart rate and plasma insulin or fasting glucose. After controlling for covariates no differences could be found in cardiac structure or function among quintiles of non-optimal blood pressure. Furthermore in Cox regression analysis, within participants with non-optimal blood pressure, higher blood pressure was not associated with a higher rate of CV events. In the presence of MS, non-optimal blood pressure is related to abnormal LV geometry and function, and associated with increased risk for CV events. When MS is present, blood pressure ≥130/85mmHg is as effective a marker to identify individuals with cardiac abnormalities as is the traditional definition of hypertension in individuals without the MS, and should lead to more aggressive treatment." @default.
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• W2036704572 date "2003-05-01" @default.
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• W2036704572 title "Impact of blood pressure on cardiac structure and cardiovascular outcome in the metabolic syndrome: the strong heart study" @default.
• W2036704572 doi "https://doi.org/10.1016/s0895-7061(03)00689-7" @default.
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