Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036706735> ?p ?o ?g. }
- W2036706735 endingPage "14" @default.
- W2036706735 startingPage "1" @default.
- W2036706735 abstract "Most tumours arise through clonal selection and waves of expansion of a somatic cell that has acquired genetic alterations in essential genes either controlling cell death or cell proliferation. Furthermore, stability of the genome in cancer cells becomes precarious and compromised because several cancer-predisposing mutations affect genes that are responsible for maintaining the integrity and number of chromosomes during cell division. Consequently, the archetypical transformation in tumour cells results in aneuploidy. Indeed, almost all tumour cells display a host of karyotype alterations, showing translocations, gains or losses of entire or large parts of chromosomes. Cancers do not necessarily have a higher mutation rate than normal tissue at the nucleotide level, unless they have gained a mutator phenotype through exposure to environmental stress, but rather exhibit gross chromosomal changes. Therefore, it appears that the main mechanism of tumour progression stems from chromosome instability. Chromosomal instability prevailing in tumour cells arises through several different pathways and is probably controlled by hundreds of genes. Therefore, this review describes the main factors that control chromosome stability through telomere maintenance, mechanisms of cell division, and the mitotic checkpoints that govern centrosome duplication and correct chromosome segregation." @default.
- W2036706735 created "2016-06-24" @default.
- W2036706735 creator A5014138122 @default.
- W2036706735 creator A5019366627 @default.
- W2036706735 date "2006-07-01" @default.
- W2036706735 modified "2023-10-07" @default.
- W2036706735 title "Mechanisms of chromosome instability in cancers" @default.
- W2036706735 cites W1485522487 @default.
- W2036706735 cites W1496772673 @default.
- W2036706735 cites W1502721583 @default.
- W2036706735 cites W1541877559 @default.
- W2036706735 cites W1543500873 @default.
- W2036706735 cites W1544851750 @default.
- W2036706735 cites W1545398558 @default.
- W2036706735 cites W1552282019 @default.
- W2036706735 cites W1556655356 @default.
- W2036706735 cites W1593569677 @default.
- W2036706735 cites W1600373583 @default.
- W2036706735 cites W1852455217 @default.
- W2036706735 cites W1886278373 @default.
- W2036706735 cites W1964151664 @default.
- W2036706735 cites W1964543951 @default.
- W2036706735 cites W1965828039 @default.
- W2036706735 cites W1966631570 @default.
- W2036706735 cites W1966826646 @default.
- W2036706735 cites W1967304777 @default.
- W2036706735 cites W1968407767 @default.
- W2036706735 cites W1971708555 @default.
- W2036706735 cites W1976067971 @default.
- W2036706735 cites W1976273464 @default.
- W2036706735 cites W1980470053 @default.
- W2036706735 cites W1981132305 @default.
- W2036706735 cites W1983673827 @default.
- W2036706735 cites W1984542357 @default.
- W2036706735 cites W1984825396 @default.
- W2036706735 cites W1986937402 @default.
- W2036706735 cites W1990085600 @default.
- W2036706735 cites W1990892778 @default.
- W2036706735 cites W1992181243 @default.
- W2036706735 cites W1994060558 @default.
- W2036706735 cites W1995405908 @default.
- W2036706735 cites W1995819860 @default.
- W2036706735 cites W1998016720 @default.
- W2036706735 cites W1998663807 @default.
- W2036706735 cites W1999002383 @default.
- W2036706735 cites W2000971601 @default.
- W2036706735 cites W2002301449 @default.
- W2036706735 cites W2011912935 @default.
- W2036706735 cites W2013073993 @default.
- W2036706735 cites W2013743651 @default.
- W2036706735 cites W2014205228 @default.
- W2036706735 cites W2020329784 @default.
- W2036706735 cites W2020382936 @default.
- W2036706735 cites W2020405679 @default.
- W2036706735 cites W2021244375 @default.
- W2036706735 cites W2021643453 @default.
- W2036706735 cites W2021758398 @default.
- W2036706735 cites W2022317339 @default.
- W2036706735 cites W2024209230 @default.
- W2036706735 cites W2024394181 @default.
- W2036706735 cites W2024619097 @default.
- W2036706735 cites W2025791374 @default.
- W2036706735 cites W2025829112 @default.
- W2036706735 cites W2026856852 @default.
- W2036706735 cites W2027779909 @default.
- W2036706735 cites W2030976397 @default.
- W2036706735 cites W2032407757 @default.
- W2036706735 cites W2033230283 @default.
- W2036706735 cites W2033731825 @default.
- W2036706735 cites W2034269086 @default.
- W2036706735 cites W2037607661 @default.
- W2036706735 cites W2040154374 @default.
- W2036706735 cites W2043204829 @default.
- W2036706735 cites W2044643325 @default.
- W2036706735 cites W2047246362 @default.
- W2036706735 cites W2053496633 @default.
- W2036706735 cites W2057712396 @default.
- W2036706735 cites W2059190311 @default.
- W2036706735 cites W2063070639 @default.
- W2036706735 cites W2065423665 @default.
- W2036706735 cites W2068270991 @default.
- W2036706735 cites W2072744580 @default.
- W2036706735 cites W2072751885 @default.
- W2036706735 cites W2075700583 @default.
- W2036706735 cites W2076791200 @default.
- W2036706735 cites W2077060586 @default.
- W2036706735 cites W2078358000 @default.
- W2036706735 cites W2080952568 @default.
- W2036706735 cites W2085283608 @default.
- W2036706735 cites W2087011288 @default.
- W2036706735 cites W2088672106 @default.
- W2036706735 cites W2088926897 @default.
- W2036706735 cites W2089685532 @default.
- W2036706735 cites W2090083872 @default.
- W2036706735 cites W2090189277 @default.
- W2036706735 cites W2095317270 @default.
- W2036706735 cites W2096107753 @default.
- W2036706735 cites W2096136751 @default.