FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036707049> ?p ?o ?g. }

• W2036707049 endingPage "17" @default.
• W2036707049 startingPage "7" @default.
• W2036707049 abstract "Our previous data showed that vitamin A deficiency (VAD) induces, in whole brain, a reduced amount of mRNA for brain retinoic acid (RA) and triiodothyronine (T3) nuclear receptors (i.e., RAR, RXR, and TR, respectively), which is accompanied by reduced amounts of mRNA and protein of neurogranin (RC3, a neuronal protein involved in synaptic plasticity) as well as selective behavioral impairment. Given the important role of retinoids for optimal brain functioning, the effects of vitamin A depletion and subsequent administration of RA or T3 on the mRNA levels of RA and T3 nuclear receptors and on two target genes' (RC3 and neuromodulin or GAP43) mRNA and protein levels were examined in the hippocampus, striatum, and cerebral cortex. A quantitative real-time polymerase chain reaction (PCR), in situ hybridization, and Western blot analysis demonstrated that the striatal region is the brain site where both RA and T3 signaling pathways are most affected by VAD. Indeed, rats fed a vitamin A-free diet for 10 weeks exhibited decreased expression of RAR, RXR, TR, RC3, and GAP43 in the striatum. The administration of T3 to these vitamin A-deprived rats reversed the reduction in mRNA levels of RA and T3 nuclear receptors and in mRNA and protein levels of target genes in this region. These data suggest that modifications that appear preferentially in the striatum, a region highly sensitive to vitamin A bioavailability, may contribute to neurobiological alterations and the spatial learning impairment that occurs in vitamin A-deprived animals." @default.
• W2036707049 created "2016-06-24" @default.
• W2036707049 creator A5029006067 @default.
• W2036707049 creator A5062402563 @default.
• W2036707049 creator A5062869789 @default.
• W2036707049 creator A5079912098 @default.
• W2036707049 creator A5086939449 @default.
• W2036707049 creator A5088275401 @default.
• W2036707049 date "2004-04-01" @default.
• W2036707049 modified "2023-09-23" @default.
• W2036707049 title "Expression of neurogranin and neuromodulin is affected in the striatum of vitamin A-deprived rats" @default.
• W2036707049 cites W1527976882 @default.
• W2036707049 cites W1557317938 @default.
• W2036707049 cites W1587319566 @default.
• W2036707049 cites W1966123992 @default.
• W2036707049 cites W1966297878 @default.
• W2036707049 cites W1966316797 @default.
• W2036707049 cites W1967868407 @default.
• W2036707049 cites W1968164494 @default.
• W2036707049 cites W1976405146 @default.
• W2036707049 cites W1984704475 @default.
• W2036707049 cites W1999170657 @default.
• W2036707049 cites W2019326141 @default.
• W2036707049 cites W2021866217 @default.
• W2036707049 cites W2022072930 @default.
• W2036707049 cites W2024822097 @default.
• W2036707049 cites W2025631499 @default.
• W2036707049 cites W2031418608 @default.
• W2036707049 cites W2032724628 @default.
• W2036707049 cites W2037334669 @default.
• W2036707049 cites W2041051313 @default.
• W2036707049 cites W2041866421 @default.
• W2036707049 cites W2043935934 @default.
• W2036707049 cites W2044212322 @default.
• W2036707049 cites W2047673461 @default.
• W2036707049 cites W2049776725 @default.
• W2036707049 cites W2054013982 @default.
• W2036707049 cites W2054504986 @default.
• W2036707049 cites W2059406298 @default.
• W2036707049 cites W2062090669 @default.
• W2036707049 cites W2071230039 @default.
• W2036707049 cites W2075983350 @default.
• W2036707049 cites W2077906120 @default.
• W2036707049 cites W2081624646 @default.
• W2036707049 cites W2087592242 @default.
• W2036707049 cites W2110264624 @default.
• W2036707049 cites W2239673512 @default.
• W2036707049 cites W2465700402 @default.
• W2036707049 cites W4241960023 @default.
• W2036707049 cites W4243904555 @default.
• W2036707049 cites W4255806751 @default.
• W2036707049 cites W4293247451 @default.
• W2036707049 cites W47545943 @default.
• W2036707049 doi "https://doi.org/10.1016/j.molbrainres.2003.12.012" @default.
• W2036707049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15046861" @default.
• W2036707049 hasPublicationYear "2004" @default.
• W2036707049 type Work @default.
• W2036707049 sameAs 2036707049 @default.
• W2036707049 citedByCount "61" @default.
• W2036707049 countsByYear W20367070492012 @default.
• W2036707049 countsByYear W20367070492013 @default.
• W2036707049 countsByYear W20367070492014 @default.
• W2036707049 countsByYear W20367070492015 @default.
• W2036707049 countsByYear W20367070492016 @default.
• W2036707049 countsByYear W20367070492017 @default.
• W2036707049 countsByYear W20367070492018 @default.
• W2036707049 countsByYear W20367070492019 @default.
• W2036707049 countsByYear W20367070492020 @default.
• W2036707049 countsByYear W20367070492021 @default.
• W2036707049 countsByYear W20367070492022 @default.
• W2036707049 crossrefType "journal-article" @default.
• W2036707049 hasAuthorship W2036707049A5029006067 @default.
• W2036707049 hasAuthorship W2036707049A5062402563 @default.
• W2036707049 hasAuthorship W2036707049A5062869789 @default.
• W2036707049 hasAuthorship W2036707049A5079912098 @default.
• W2036707049 hasAuthorship W2036707049A5086939449 @default.
• W2036707049 hasAuthorship W2036707049A5088275401 @default.
• W2036707049 hasConcept C104317684 @default.
• W2036707049 hasConcept C105580179 @default.
• W2036707049 hasConcept C126322002 @default.
• W2036707049 hasConcept C134018914 @default.
• W2036707049 hasConcept C195794163 @default.
• W2036707049 hasConcept C204232928 @default.
• W2036707049 hasConcept C2776940978 @default.
• W2036707049 hasConcept C2780062018 @default.
• W2036707049 hasConcept C2780748493 @default.
• W2036707049 hasConcept C2781121885 @default.
• W2036707049 hasConcept C513476851 @default.
• W2036707049 hasConcept C55493867 @default.
• W2036707049 hasConcept C62478195 @default.
• W2036707049 hasConcept C71924100 @default.
• W2036707049 hasConcept C81439078 @default.
• W2036707049 hasConcept C86803240 @default.
• W2036707049 hasConcept C90770895 @default.
• W2036707049 hasConcept C95444343 @default.
• W2036707049 hasConceptScore W2036707049C104317684 @default.
• W2036707049 hasConceptScore W2036707049C105580179 @default.
• W2036707049 hasConceptScore W2036707049C126322002 @default.

• next