FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036707419> ?p ?o ?g. }

• W2036707419 endingPage "254" @default.
• W2036707419 startingPage "250" @default.
• W2036707419 abstract "Accumulating evidence indicates that aged black garlic extract (ABGE) may prove beneficial in preventing or inhibiting oncogenesis; however, the underlying mechanisms have not been fully elucidated. The present study aimed to investigate the effects of ABGE on the proliferation and apoptosis of Ht29 colon cancer cells. Our results demonstrated that ABGE inhibited Ht29 cell growth via the induction of apoptosis and cell cycle arrest. We further investigated the phosphatidylinositol 3‑kinase̸protein kinase B (PI3K̸Akt) signal transduction pathway and the molecular mechanisms underlying the ABGE‑induced inhibition of Ht29 cell proliferation. We observed that ABGE may regulate the function of the PI3K̸Akt pathway through upregulating PTEN and downregulating Akt and p‑Akt expression, as well as suppressing its downstream target, 70-kDa ribosomal protein S6 kinase 1, at the mrna and protein levels. In conclusion, these findings suggest that the PI3K̸Akt signal transduction pathway is crucial for the development of colon cancer. ABGE inhibited the growth and induced apoptosis in Ht29 cells through the inhibition of the PI3K̸Akt pathway, suggesting that ABGE may be effective in the prevention and treatment of colon cancer in humans." @default.
• W2036707419 created "2016-06-24" @default.
• W2036707419 creator A5011733673 @default.
• W2036707419 creator A5045560940 @default.
• W2036707419 creator A5047721804 @default.
• W2036707419 creator A5051714019 @default.
• W2036707419 creator A5058328352 @default.
• W2036707419 creator A5059098069 @default.
• W2036707419 creator A5082246930 @default.
• W2036707419 date "2014-01-20" @default.
• W2036707419 modified "2023-09-27" @default.
• W2036707419 title "Aged black garlic extract inhibits HT29 colon cancer cell growth via the PI3K/Akt signaling pathway" @default.
• W2036707419 cites W1977064103 @default.
• W2036707419 cites W2011426105 @default.
• W2036707419 cites W2018228950 @default.
• W2036707419 cites W2025663272 @default.
• W2036707419 cites W2055501079 @default.
• W2036707419 cites W2066659565 @default.
• W2036707419 cites W2073615256 @default.
• W2036707419 cites W2076627331 @default.
• W2036707419 cites W2104118000 @default.
• W2036707419 cites W2106036365 @default.
• W2036707419 cites W2109871727 @default.
• W2036707419 cites W2121087867 @default.
• W2036707419 cites W2128928017 @default.
• W2036707419 cites W2139095510 @default.
• W2036707419 cites W2145822440 @default.
• W2036707419 cites W2166558639 @default.
• W2036707419 cites W2171514265 @default.
• W2036707419 cites W2407165303 @default.
• W2036707419 doi "https://doi.org/10.3892/br.2014.226" @default.
• W2036707419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3917757" @default.
• W2036707419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24649105" @default.
• W2036707419 hasPublicationYear "2014" @default.
• W2036707419 type Work @default.
• W2036707419 sameAs 2036707419 @default.
• W2036707419 citedByCount "69" @default.
• W2036707419 countsByYear W20367074192014 @default.
• W2036707419 countsByYear W20367074192015 @default.
• W2036707419 countsByYear W20367074192016 @default.
• W2036707419 countsByYear W20367074192017 @default.
• W2036707419 countsByYear W20367074192018 @default.
• W2036707419 countsByYear W20367074192019 @default.
• W2036707419 countsByYear W20367074192020 @default.
• W2036707419 countsByYear W20367074192021 @default.
• W2036707419 countsByYear W20367074192022 @default.
• W2036707419 countsByYear W20367074192023 @default.
• W2036707419 crossrefType "journal-article" @default.
• W2036707419 hasAuthorship W2036707419A5011733673 @default.
• W2036707419 hasAuthorship W2036707419A5045560940 @default.
• W2036707419 hasAuthorship W2036707419A5047721804 @default.
• W2036707419 hasAuthorship W2036707419A5051714019 @default.
• W2036707419 hasAuthorship W2036707419A5058328352 @default.
• W2036707419 hasAuthorship W2036707419A5059098069 @default.
• W2036707419 hasAuthorship W2036707419A5082246930 @default.
• W2036707419 hasBestOaLocation W20367074191 @default.
• W2036707419 hasConcept C104202773 @default.
• W2036707419 hasConcept C121608353 @default.
• W2036707419 hasConcept C184235292 @default.
• W2036707419 hasConcept C185592680 @default.
• W2036707419 hasConcept C190283241 @default.
• W2036707419 hasConcept C2777609662 @default.
• W2036707419 hasConcept C2780044377 @default.
• W2036707419 hasConcept C2781018059 @default.
• W2036707419 hasConcept C29537977 @default.
• W2036707419 hasConcept C502942594 @default.
• W2036707419 hasConcept C54355233 @default.
• W2036707419 hasConcept C55493867 @default.
• W2036707419 hasConcept C555283112 @default.
• W2036707419 hasConcept C62112901 @default.
• W2036707419 hasConcept C62478195 @default.
• W2036707419 hasConcept C75217442 @default.
• W2036707419 hasConcept C86554907 @default.
• W2036707419 hasConcept C86803240 @default.
• W2036707419 hasConcept C95444343 @default.
• W2036707419 hasConceptScore W2036707419C104202773 @default.
• W2036707419 hasConceptScore W2036707419C121608353 @default.
• W2036707419 hasConceptScore W2036707419C184235292 @default.
• W2036707419 hasConceptScore W2036707419C185592680 @default.
• W2036707419 hasConceptScore W2036707419C190283241 @default.
• W2036707419 hasConceptScore W2036707419C2777609662 @default.
• W2036707419 hasConceptScore W2036707419C2780044377 @default.
• W2036707419 hasConceptScore W2036707419C2781018059 @default.
• W2036707419 hasConceptScore W2036707419C29537977 @default.
• W2036707419 hasConceptScore W2036707419C502942594 @default.
• W2036707419 hasConceptScore W2036707419C54355233 @default.
• W2036707419 hasConceptScore W2036707419C55493867 @default.
• W2036707419 hasConceptScore W2036707419C555283112 @default.
• W2036707419 hasConceptScore W2036707419C62112901 @default.
• W2036707419 hasConceptScore W2036707419C62478195 @default.
• W2036707419 hasConceptScore W2036707419C75217442 @default.
• W2036707419 hasConceptScore W2036707419C86554907 @default.
• W2036707419 hasConceptScore W2036707419C86803240 @default.
• W2036707419 hasConceptScore W2036707419C95444343 @default.
• W2036707419 hasIssue "2" @default.
• W2036707419 hasLocation W20367074191 @default.
• W2036707419 hasLocation W20367074192 @default.
• W2036707419 hasLocation W20367074193 @default.

• next