Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036707712> ?p ?o ?g. }
- W2036707712 endingPage "335" @default.
- W2036707712 startingPage "325" @default.
- W2036707712 abstract "Opiates and the opioid peptide enkephalin can cause indirect excitation of principal cortical neurons by reducing inhibitory synaptic transmission mediated by GABAergic interneurons. The mechanism by which opioids mediate these effects on interneurons is unknown, but enkephalin hyperpolarizes the somatic membrane potential of a variety of neurons in the brain, including hippocampal interneurons. We now report a new, more direct mechanism for the opioid-mediated reduction in synaptic inhibition. The enkephalin analog D-Ala2-Met5-enkephalinamide (DALA) decreases the frequency of miniature, action potential-independent, spontaneous GABAergic inhibitory postsynaptic currents (IPSCs) without causing a change in their amplitude. Thus, we conclude that DALA inhibits the action potential-independent release of GABA through a direct action on interneuronal synaptic terminals. In contrast, DALA reduces the amplitude of action potential-evoked, GABA-mediated IPSCs, as well as decreases their frequency. This suggests that the opioid-mediated inhibition of non-action potential-dependent GABA release reveals a mechanism that contributes to reducing action potential-evoked GABA release, thereby decreasing synaptic inhibition." @default.
- W2036707712 created "2016-06-24" @default.
- W2036707712 creator A5041537880 @default.
- W2036707712 creator A5071322716 @default.
- W2036707712 creator A5090066833 @default.
- W2036707712 date "1992-08-01" @default.
- W2036707712 modified "2023-09-25" @default.
- W2036707712 title "Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons" @default.
- W2036707712 cites W1758486524 @default.
- W2036707712 cites W180945370 @default.
- W2036707712 cites W1944255113 @default.
- W2036707712 cites W1966650187 @default.
- W2036707712 cites W1970096704 @default.
- W2036707712 cites W1971273652 @default.
- W2036707712 cites W1976496833 @default.
- W2036707712 cites W1977383358 @default.
- W2036707712 cites W1984405279 @default.
- W2036707712 cites W1986518778 @default.
- W2036707712 cites W1987639493 @default.
- W2036707712 cites W1988297090 @default.
- W2036707712 cites W1994364267 @default.
- W2036707712 cites W1996382884 @default.
- W2036707712 cites W1996409976 @default.
- W2036707712 cites W1996892917 @default.
- W2036707712 cites W1999950160 @default.
- W2036707712 cites W2015677561 @default.
- W2036707712 cites W2029308903 @default.
- W2036707712 cites W2031674252 @default.
- W2036707712 cites W2036320267 @default.
- W2036707712 cites W2038299024 @default.
- W2036707712 cites W2039231750 @default.
- W2036707712 cites W2041058421 @default.
- W2036707712 cites W2042701641 @default.
- W2036707712 cites W2044215405 @default.
- W2036707712 cites W2060094414 @default.
- W2036707712 cites W2061042379 @default.
- W2036707712 cites W2063224843 @default.
- W2036707712 cites W2069039551 @default.
- W2036707712 cites W2077343981 @default.
- W2036707712 cites W2081228472 @default.
- W2036707712 cites W2085930977 @default.
- W2036707712 cites W2088296164 @default.
- W2036707712 cites W2091053227 @default.
- W2036707712 cites W2093428018 @default.
- W2036707712 cites W2094787900 @default.
- W2036707712 cites W2099834228 @default.
- W2036707712 cites W2122130593 @default.
- W2036707712 cites W2169863475 @default.
- W2036707712 cites W2411932594 @default.
- W2036707712 cites W2416580448 @default.
- W2036707712 cites W86237330 @default.
- W2036707712 doi "https://doi.org/10.1016/0896-6273(92)90171-9" @default.
- W2036707712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1497896" @default.
- W2036707712 hasPublicationYear "1992" @default.
- W2036707712 type Work @default.
- W2036707712 sameAs 2036707712 @default.
- W2036707712 citedByCount "259" @default.
- W2036707712 countsByYear W20367077122012 @default.
- W2036707712 countsByYear W20367077122013 @default.
- W2036707712 countsByYear W20367077122014 @default.
- W2036707712 countsByYear W20367077122015 @default.
- W2036707712 countsByYear W20367077122016 @default.
- W2036707712 countsByYear W20367077122017 @default.
- W2036707712 countsByYear W20367077122018 @default.
- W2036707712 countsByYear W20367077122019 @default.
- W2036707712 countsByYear W20367077122020 @default.
- W2036707712 countsByYear W20367077122021 @default.
- W2036707712 countsByYear W20367077122023 @default.
- W2036707712 crossrefType "journal-article" @default.
- W2036707712 hasAuthorship W2036707712A5041537880 @default.
- W2036707712 hasAuthorship W2036707712A5071322716 @default.
- W2036707712 hasAuthorship W2036707712A5090066833 @default.
- W2036707712 hasConcept C148762608 @default.
- W2036707712 hasConcept C169760540 @default.
- W2036707712 hasConcept C170493617 @default.
- W2036707712 hasConcept C17077164 @default.
- W2036707712 hasConcept C185592680 @default.
- W2036707712 hasConcept C197341189 @default.
- W2036707712 hasConcept C200170125 @default.
- W2036707712 hasConcept C2777803847 @default.
- W2036707712 hasConcept C2779177108 @default.
- W2036707712 hasConcept C2779296341 @default.
- W2036707712 hasConcept C2781063702 @default.
- W2036707712 hasConcept C55493867 @default.
- W2036707712 hasConcept C86803240 @default.
- W2036707712 hasConcept C88016717 @default.
- W2036707712 hasConceptScore W2036707712C148762608 @default.
- W2036707712 hasConceptScore W2036707712C169760540 @default.
- W2036707712 hasConceptScore W2036707712C170493617 @default.
- W2036707712 hasConceptScore W2036707712C17077164 @default.
- W2036707712 hasConceptScore W2036707712C185592680 @default.
- W2036707712 hasConceptScore W2036707712C197341189 @default.
- W2036707712 hasConceptScore W2036707712C200170125 @default.
- W2036707712 hasConceptScore W2036707712C2777803847 @default.
- W2036707712 hasConceptScore W2036707712C2779177108 @default.
- W2036707712 hasConceptScore W2036707712C2779296341 @default.
- W2036707712 hasConceptScore W2036707712C2781063702 @default.
- W2036707712 hasConceptScore W2036707712C55493867 @default.