Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036708427> ?p ?o ?g. }
- W2036708427 endingPage "117" @default.
- W2036708427 startingPage "108" @default.
- W2036708427 abstract "As in other fields of biomedical research, the use of gene-targeted mice by homologous recombination in embryonic stem cells has provided important findings on the function of several members of the protein tyrosine phosphatase (PTP) family. For instance, the phenotypic characterization of knockout mice has been critical in understanding the sites of action of the related PTPs protein tyrosine phosphatase 1B (PTP1B) and T-cell-PTP (TC-PTP). By their increased insulin sensitivity and insulin receptor hyperphosphorylation, PTP1B null mice demonstrated a clear function for this enzyme as a negative regulator of insulin signaling. As well, TC-PTP has also been recently involved in insulin signaling in vitro. Importantly, the high identity in their amino acid sequences suggests that they must be examined simultaneously as targets of drug development. Indeed, they possess different as well as overlapping substrates, which suggest complementary and overlapping roles of both TC-PTP and PTP1B. Here, we review the function of PTP1B and TC-PTP in diabetes, obesity, and processes related to cancer." @default.
- W2036708427 created "2016-06-24" @default.
- W2036708427 creator A5001584238 @default.
- W2036708427 creator A5007653418 @default.
- W2036708427 date "2005-12-01" @default.
- W2036708427 modified "2023-10-18" @default.
- W2036708427 title "Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: From diabetes, obesity to cell cycle, and cancer" @default.
- W2036708427 cites W1484619869 @default.
- W2036708427 cites W1512072195 @default.
- W2036708427 cites W1600880434 @default.
- W2036708427 cites W1639582946 @default.
- W2036708427 cites W1973077331 @default.
- W2036708427 cites W1973667360 @default.
- W2036708427 cites W1973875557 @default.
- W2036708427 cites W1976382352 @default.
- W2036708427 cites W1979140242 @default.
- W2036708427 cites W1980814049 @default.
- W2036708427 cites W1981673694 @default.
- W2036708427 cites W1982603741 @default.
- W2036708427 cites W1983089513 @default.
- W2036708427 cites W1988456343 @default.
- W2036708427 cites W1995088117 @default.
- W2036708427 cites W1998878926 @default.
- W2036708427 cites W2002320258 @default.
- W2036708427 cites W2004755427 @default.
- W2036708427 cites W2005076200 @default.
- W2036708427 cites W2005955483 @default.
- W2036708427 cites W2006835948 @default.
- W2036708427 cites W2007551386 @default.
- W2036708427 cites W2008707603 @default.
- W2036708427 cites W2011318675 @default.
- W2036708427 cites W2013355944 @default.
- W2036708427 cites W2014129040 @default.
- W2036708427 cites W2016074758 @default.
- W2036708427 cites W2019032255 @default.
- W2036708427 cites W2019396874 @default.
- W2036708427 cites W2019957038 @default.
- W2036708427 cites W2020018765 @default.
- W2036708427 cites W2020267609 @default.
- W2036708427 cites W2022215206 @default.
- W2036708427 cites W2022249390 @default.
- W2036708427 cites W2023058928 @default.
- W2036708427 cites W2023423740 @default.
- W2036708427 cites W2025143050 @default.
- W2036708427 cites W2025316432 @default.
- W2036708427 cites W2026671374 @default.
- W2036708427 cites W2027981450 @default.
- W2036708427 cites W2029342409 @default.
- W2036708427 cites W2030253887 @default.
- W2036708427 cites W2033443838 @default.
- W2036708427 cites W2037434509 @default.
- W2036708427 cites W2039283984 @default.
- W2036708427 cites W2040780260 @default.
- W2036708427 cites W2041182684 @default.
- W2036708427 cites W2043188148 @default.
- W2036708427 cites W2043617798 @default.
- W2036708427 cites W2046766433 @default.
- W2036708427 cites W2051201358 @default.
- W2036708427 cites W2051381737 @default.
- W2036708427 cites W2052506761 @default.
- W2036708427 cites W2053544216 @default.
- W2036708427 cites W2053674933 @default.
- W2036708427 cites W2054575721 @default.
- W2036708427 cites W2055496927 @default.
- W2036708427 cites W2055910783 @default.
- W2036708427 cites W2056030232 @default.
- W2036708427 cites W2059670606 @default.
- W2036708427 cites W2062767127 @default.
- W2036708427 cites W2063389197 @default.
- W2036708427 cites W2069069354 @default.
- W2036708427 cites W2070582535 @default.
- W2036708427 cites W2071522285 @default.
- W2036708427 cites W2076822732 @default.
- W2036708427 cites W2080175465 @default.
- W2036708427 cites W2080932392 @default.
- W2036708427 cites W2082828361 @default.
- W2036708427 cites W2086493034 @default.
- W2036708427 cites W2087094332 @default.
- W2036708427 cites W2087482176 @default.
- W2036708427 cites W2093007337 @default.
- W2036708427 cites W2095024386 @default.
- W2036708427 cites W2096415262 @default.
- W2036708427 cites W2099224719 @default.
- W2036708427 cites W2104992365 @default.
- W2036708427 cites W2105682644 @default.
- W2036708427 cites W2107050190 @default.
- W2036708427 cites W2112209988 @default.
- W2036708427 cites W2114943013 @default.
- W2036708427 cites W2115681043 @default.
- W2036708427 cites W2116500202 @default.
- W2036708427 cites W2119849736 @default.
- W2036708427 cites W2122898723 @default.
- W2036708427 cites W2123229219 @default.
- W2036708427 cites W2123935496 @default.
- W2036708427 cites W2125797784 @default.
- W2036708427 cites W2133235979 @default.
- W2036708427 cites W2135896596 @default.
- W2036708427 cites W2139144434 @default.