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• W2036709321 abstract "It is unclear whether delays in commencing adjuvant chemotherapy after surgical resection of colon adenocarcinoma adversely impact survival.Patients with stage II-III colon adenocarcinoma who received adjuvant chemotherapy at 2 centers were identified through the institutional tumor registry. Time to adjuvant chemotherapy, overall survival (OS), and relapse-free survival (RFS) were calculated from the day of surgery. Patients were dichotomized into early (time to adjuvant chemotherapy ≤ 60 days) and late treatment (time to adjuvant chemotherapy >60 days) groups. OS and RFS were compared using log-rank test and multivariate analysis by the Cox proportional hazards model.Of 186 patients included in the study, 49 (26%) had received adjuvant chemotherapy >60 days after surgical resection. Thirty percent of the delays were system related (eg, late referrals, insurance authorizations). Time to adjuvant chemotherapy >60 days was associated with significantly worse OS in both univariate analysis and a Cox proportional hazards model (hazard ratio, 2.17; 95% confidence interval, 1.08-4.36). Although difference in RFS between the 2 groups favored time to adjuvant chemotherapy <60, this did not reach statistical significance.Adjuvant chemotherapy delay >60 days after surgical resection of colon cancer is associated with worse OS." @default.
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• W2036709321 date "2010-12-17" @default.
• W2036709321 modified "2023-10-16" @default.
• W2036709321 title "Does delay of adjuvant chemotherapy impact survival in patients with resected stage II and III colon adenocarcinoma?" @default.
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• W2036709321 doi "https://doi.org/10.1002/cncr.25720" @default.
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