Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036712153> ?p ?o ?g. }
- W2036712153 endingPage "587" @default.
- W2036712153 startingPage "577" @default.
- W2036712153 abstract "HOXA10 is a member of the HOX family of regulatory genes that are involved in hematopoiesis. Its role in megakaryopoiesis has been suggested by its expression in immature megakaryocytes and by the proliferation of megakaryocyte-primitive blast colonies upon HOXA10 overexpression. We sought to understand the role of HOXA10 in megakaryopoiesis better, by investigating its transcriptional regulation. Analysis of the 5' untranslated region and transfection of promoter/plasmids into human tissue culture cell lines identified transcriptionally active sequences that contain GATA-1 and Ets-1 sites and a putative binding site for its neighboring gene, HOXA11. Gel shift assays confirmed protein-DNA interactions at these sites. Mutation of the GATA-1 and the Ets-1 motifs amplified the expression of HOXA10 in HEL and K562 cells, confirming the importance of these cis-acting elements in regulating HOXA10 expression in megakaryocytic cells. Chromatin immunoprecipitation (ChIP) and chloramphenicol acetyl transferase (CAT) assays confirm that HOXA11 binds to the putative binding site, resulting in repression of HOXA10 expression. These data taken together give insight into the regulation of HOXA10 expression in megakaryocytic differentiation." @default.
- W2036712153 created "2016-06-24" @default.
- W2036712153 creator A5038535078 @default.
- W2036712153 creator A5041793797 @default.
- W2036712153 creator A5071561779 @default.
- W2036712153 date "2007-08-01" @default.
- W2036712153 modified "2023-10-16" @default.
- W2036712153 title "Transcription Factors GATA-1 and Fli-1 Regulate Human HOXA10 Expression in Megakaryocytic Cells" @default.
- W2036712153 cites W1522943639 @default.
- W2036712153 cites W1529111943 @default.
- W2036712153 cites W1598647766 @default.
- W2036712153 cites W187246154 @default.
- W2036712153 cites W1881764688 @default.
- W2036712153 cites W1969012158 @default.
- W2036712153 cites W1970008456 @default.
- W2036712153 cites W1971862881 @default.
- W2036712153 cites W1972561843 @default.
- W2036712153 cites W1973110404 @default.
- W2036712153 cites W1976386009 @default.
- W2036712153 cites W1978932030 @default.
- W2036712153 cites W1985540245 @default.
- W2036712153 cites W1991419585 @default.
- W2036712153 cites W1993243592 @default.
- W2036712153 cites W1995780901 @default.
- W2036712153 cites W1996234453 @default.
- W2036712153 cites W1999753557 @default.
- W2036712153 cites W2003106200 @default.
- W2036712153 cites W2008494281 @default.
- W2036712153 cites W2014049270 @default.
- W2036712153 cites W2026384939 @default.
- W2036712153 cites W2028182935 @default.
- W2036712153 cites W2031498265 @default.
- W2036712153 cites W2036513942 @default.
- W2036712153 cites W2038676896 @default.
- W2036712153 cites W2043205719 @default.
- W2036712153 cites W2044091568 @default.
- W2036712153 cites W2054816172 @default.
- W2036712153 cites W2055188073 @default.
- W2036712153 cites W2055759255 @default.
- W2036712153 cites W2058127668 @default.
- W2036712153 cites W2060515433 @default.
- W2036712153 cites W2061633616 @default.
- W2036712153 cites W2062474573 @default.
- W2036712153 cites W2062604372 @default.
- W2036712153 cites W2063556118 @default.
- W2036712153 cites W2065119107 @default.
- W2036712153 cites W2070028842 @default.
- W2036712153 cites W2074635617 @default.
- W2036712153 cites W2084460030 @default.
- W2036712153 cites W2091909421 @default.
- W2036712153 cites W2092892794 @default.
- W2036712153 cites W2095297122 @default.
- W2036712153 cites W2105635571 @default.
- W2036712153 cites W2108867862 @default.
- W2036712153 cites W2110519255 @default.
- W2036712153 cites W2116230332 @default.
- W2036712153 cites W2118598660 @default.
- W2036712153 cites W2128491068 @default.
- W2036712153 cites W2135486939 @default.
- W2036712153 cites W2143615866 @default.
- W2036712153 cites W2145415222 @default.
- W2036712153 cites W2147074981 @default.
- W2036712153 cites W2147751805 @default.
- W2036712153 cites W2148381770 @default.
- W2036712153 cites W2169026057 @default.
- W2036712153 cites W4256265928 @default.
- W2036712153 cites W66848399 @default.
- W2036712153 doi "https://doi.org/10.1089/dna.2007.0575" @default.
- W2036712153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17688409" @default.
- W2036712153 hasPublicationYear "2007" @default.
- W2036712153 type Work @default.
- W2036712153 sameAs 2036712153 @default.
- W2036712153 citedByCount "8" @default.
- W2036712153 countsByYear W20367121532013 @default.
- W2036712153 countsByYear W20367121532014 @default.
- W2036712153 countsByYear W20367121532015 @default.
- W2036712153 countsByYear W20367121532021 @default.
- W2036712153 crossrefType "journal-article" @default.
- W2036712153 hasAuthorship W2036712153A5038535078 @default.
- W2036712153 hasAuthorship W2036712153A5041793797 @default.
- W2036712153 hasAuthorship W2036712153A5071561779 @default.
- W2036712153 hasConcept C101762097 @default.
- W2036712153 hasConcept C104317684 @default.
- W2036712153 hasConcept C134320426 @default.
- W2036712153 hasConcept C150194340 @default.
- W2036712153 hasConcept C153911025 @default.
- W2036712153 hasConcept C165864922 @default.
- W2036712153 hasConcept C54009773 @default.
- W2036712153 hasConcept C54355233 @default.
- W2036712153 hasConcept C83640560 @default.
- W2036712153 hasConcept C86339819 @default.
- W2036712153 hasConcept C86803240 @default.
- W2036712153 hasConceptScore W2036712153C101762097 @default.
- W2036712153 hasConceptScore W2036712153C104317684 @default.
- W2036712153 hasConceptScore W2036712153C134320426 @default.
- W2036712153 hasConceptScore W2036712153C150194340 @default.
- W2036712153 hasConceptScore W2036712153C153911025 @default.
- W2036712153 hasConceptScore W2036712153C165864922 @default.