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• W2036713508 abstract "Objective: A challenge for all IVF programs is how to maximize the ovarian response in those women who are considered to be poor responders. The purpose of this study was to examine our experience with a group of poor responders who were administered a GnRH antagonist, ganirelix acetate, as part of their ovulation induction protocol. Design: Retrospective study. Materials/Methods: Our database identified 52 IVF cycles that incorporated the use of a GnRH antagonist, ganirelix acetate (Antagon®). Thirty-three of these cycles (the subject of this report) were performed on poor responders, as defined by a prior cycle with <3 follicles or peak estradiol level <500 pg/ml, or the daily requirement of 450 IU or more of gonadotropins. Patients received gonadotropins, 450-600 IU per day beginning on day 2 of the cycle. Ganirelix acetate, 0.25 mg daily was begun when the lead follicle was ≥14 mm and was mixed with the FSH to be given as a single injection. When adequate follicular development had occurred and the lead follicle had reached 17 mm in diameter, hCG was administered and the egg retrieval was scheduled. Results: This study involved the analysis of 33 cycles. The mean age, cycle number and cycle day 3 FSH level was 38.5 years, 3.1 and 9.1 mIU/mL, respectively. Of the 33 total cycles, 10 (30%) were cancelled and 23 (70%) went on to the egg retrieval. Of the 10 cycles that were cancelled, 9 were cancelled because of poor follicular recruitment confirmed before the ganirelix was started. One cycle was cancelled because of decreasing serum estradiol levels after the ganirelix was begun. There were no differences between cancelled and completed cycles with respect to age (38.7 vs. 39.4 years) and cycle day 3 FSH levels (9.4 vs. 9.1 mIU/mL). In the 23 completed cycles the mean peak serum estradiol level, number of eggs retrieved and number of embryos transferred was 888 pg/ml, 5.7, and 2.8, respectively. A total of 8 cycles (35% of egg retrievals) resulted in a pregnancy of which, three resulted in an early pregnancy loss and five pregnancies are ongoing. Conclusions: This preliminary study suggests that a GnRH antagonist combined with gonadotropins for ovulation induction may prove useful in IVF patients with a prior history of a poor ovarian response." @default.
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• W2036713508 date "2001-09-01" @default.
• W2036713508 modified "2023-10-18" @default.
• W2036713508 title "Experience with the use of a GnRH antagonist in IVF patients who are poor responders." @default.
• W2036713508 doi "https://doi.org/10.1016/s0015-0282(01)02698-x" @default.
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