FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036717403> ?p ?o ?g. }

• W2036717403 endingPage "14" @default.
• W2036717403 startingPage "3" @default.
• W2036717403 abstract "Quantitative protein analysis is routinely performed in clinical chemistry laboratories for diagnosis, therapeutic monitoring, and prognosis. Today, protein assays are mostly performed either with non-specific detection methods or immunoassays. Mass spectrometry (MS) is a very specific analytical method potentially very well suited for clinical laboratories. Its unique advantage relies in the high specificity of the detection. Any protein sequence variant, the presence of a post-translational modification or degradation will differ in mass and structure, and these differences will appear in the mass spectrum of the protein. On the other hand, protein MS is a relatively young technique, demanding specialized personnel and expensive instrumentation. Many scientists and opinion leaders predict MS to replace immunoassays for routine protein analysis, but there are only few protein MS applications routinely used in clinical chemistry laboratories today. The present review consists of a didactical introduction summarizing the pros and cons of MS assays compared to immunoassays, the different instrumentations, and various MS protein assays that have been proposed and/or are used in clinical laboratories. An important distinction is made between full length protein analysis (top-down method) and peptide analysis after enzymatic digestion of the proteins (bottom-up method) and its implication for the protein assay. The document ends with an outlook on what type of analyses could be used in the future, and for what type of applications MS has a clear advantage compared to immunoassays." @default.
• W2036717403 created "2016-06-24" @default.
• W2036717403 creator A5069327263 @default.
• W2036717403 date "2015-06-01" @default.
• W2036717403 modified "2023-10-07" @default.
• W2036717403 title "Clinical protein mass spectrometry" @default.
• W2036717403 cites W1568341953 @default.
• W2036717403 cites W170968695 @default.
• W2036717403 cites W1892810170 @default.
• W2036717403 cites W1966602367 @default.
• W2036717403 cites W1971786367 @default.
• W2036717403 cites W1971983473 @default.
• W2036717403 cites W1972638274 @default.
• W2036717403 cites W1973182209 @default.
• W2036717403 cites W1974500649 @default.
• W2036717403 cites W1975121739 @default.
• W2036717403 cites W1982468602 @default.
• W2036717403 cites W1984525664 @default.
• W2036717403 cites W1984589199 @default.
• W2036717403 cites W1992345938 @default.
• W2036717403 cites W1993428041 @default.
• W2036717403 cites W2002778277 @default.
• W2036717403 cites W2006841249 @default.
• W2036717403 cites W2009015613 @default.
• W2036717403 cites W2016005409 @default.
• W2036717403 cites W2024001430 @default.
• W2036717403 cites W2028933014 @default.
• W2036717403 cites W2031557560 @default.
• W2036717403 cites W2033492963 @default.
• W2036717403 cites W2034001550 @default.
• W2036717403 cites W2034915170 @default.
• W2036717403 cites W2038301244 @default.
• W2036717403 cites W2038554914 @default.
• W2036717403 cites W2046520841 @default.
• W2036717403 cites W2048527293 @default.
• W2036717403 cites W2049107361 @default.
• W2036717403 cites W2051516411 @default.
• W2036717403 cites W2051930920 @default.
• W2036717403 cites W2056631270 @default.
• W2036717403 cites W2058906299 @default.
• W2036717403 cites W2062203307 @default.
• W2036717403 cites W2066322883 @default.
• W2036717403 cites W2067675979 @default.
• W2036717403 cites W2068481474 @default.
• W2036717403 cites W2071603036 @default.
• W2036717403 cites W2074392515 @default.
• W2036717403 cites W2074877005 @default.
• W2036717403 cites W2077003710 @default.
• W2036717403 cites W2078366690 @default.
• W2036717403 cites W2079184270 @default.
• W2036717403 cites W2081337065 @default.
• W2036717403 cites W2083684832 @default.
• W2036717403 cites W2089526161 @default.
• W2036717403 cites W2089780656 @default.
• W2036717403 cites W2092777410 @default.
• W2036717403 cites W2099973618 @default.
• W2036717403 cites W2107161977 @default.
• W2036717403 cites W2107710616 @default.
• W2036717403 cites W2107986159 @default.
• W2036717403 cites W2110958540 @default.
• W2036717403 cites W2111727769 @default.
• W2036717403 cites W2112456433 @default.
• W2036717403 cites W2112634832 @default.
• W2036717403 cites W2113331084 @default.
• W2036717403 cites W2120238753 @default.
• W2036717403 cites W2121325005 @default.
• W2036717403 cites W2122072556 @default.
• W2036717403 cites W2128564638 @default.
• W2036717403 cites W2130154577 @default.
• W2036717403 cites W2131280672 @default.
• W2036717403 cites W2131741443 @default.
• W2036717403 cites W2133501640 @default.
• W2036717403 cites W2137885916 @default.
• W2036717403 cites W2137904973 @default.
• W2036717403 cites W2141627904 @default.
• W2036717403 cites W2142127575 @default.
• W2036717403 cites W2145503040 @default.
• W2036717403 cites W2147443546 @default.
• W2036717403 cites W2164253249 @default.
• W2036717403 cites W2171081285 @default.
• W2036717403 cites W2324043133 @default.
• W2036717403 cites W2328648438 @default.
• W2036717403 cites W2616844296 @default.
• W2036717403 cites W3121589124 @default.
• W2036717403 doi "https://doi.org/10.1016/j.ymeth.2015.02.015" @default.
• W2036717403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25752846" @default.
• W2036717403 hasPublicationYear "2015" @default.
• W2036717403 type Work @default.
• W2036717403 sameAs 2036717403 @default.
• W2036717403 citedByCount "49" @default.
• W2036717403 countsByYear W20367174032015 @default.
• W2036717403 countsByYear W20367174032016 @default.
• W2036717403 countsByYear W20367174032017 @default.
• W2036717403 countsByYear W20367174032018 @default.
• W2036717403 countsByYear W20367174032019 @default.
• W2036717403 countsByYear W20367174032020 @default.
• W2036717403 countsByYear W20367174032021 @default.
• W2036717403 countsByYear W20367174032022 @default.

• next