FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036718295> ?p ?o ?g. }

• W2036718295 endingPage "2957" @default.
• W2036718295 startingPage "2954" @default.
• W2036718295 abstract "Abstract Prospective studies in cancer epidemiology have conserved their study design over the last decades. In this context, current epidemiologic studies investigating gene-environment interactions are based on biobank for the analysis of genetic variation and biomarkers, using notified cancer as outcome. These studies result from the use of high-throughput technologies rather than from the development of novel design strategies. In this article, we propose the globolomic design to run integrated analyses of cancer risk covering the major -omics in blood and tumor tissue. We defined this design as an extension of the existing prospective design by collecting tissue and blood samples at time of diagnosis, including biological material suitable for transcriptome analysis. The globolomic design opens up for several new analytic strategies and, where gene expression profiles could be used to verify mechanistic information from experimental biology, adds a new dimension to causality in epidemiology. This could improve, for example, the interpretation of risk estimates related to single nucleotide polymorphisms in gene-environment studies by changing the criterion of biological plausibility from a subjective discussion of in vitro information to observational data of human in vivo gene expression. This ambitious design should consider the complexity of the multistage carcinogenic process, the latency time, and the changing lifestyle of the cohort members. This design could open the new research discipline of systems epidemiology, defined in this article as a counterpart to systems biology. Systems epidemiology with a focus on gene functions challenges the current concept of biobanking, which focuses mainly on DNA analyses. (Cancer Epidemiol Biomarkers Prev 2008;17(11):2954–7)" @default.
• W2036718295 created "2016-06-24" @default.
• W2036718295 creator A5067257359 @default.
• W2036718295 creator A5067509213 @default.
• W2036718295 date "2008-11-01" @default.
• W2036718295 modified "2023-09-27" @default.
• W2036718295 title "Systems Epidemiology in Cancer" @default.
• W2036718295 cites W1549733517 @default.
• W2036718295 cites W1949641870 @default.
• W2036718295 cites W1979431894 @default.
• W2036718295 cites W1989336885 @default.
• W2036718295 cites W1991154912 @default.
• W2036718295 cites W1994573648 @default.
• W2036718295 cites W1996647803 @default.
• W2036718295 cites W1997647949 @default.
• W2036718295 cites W2002310413 @default.
• W2036718295 cites W2026252313 @default.
• W2036718295 cites W2028361287 @default.
• W2036718295 cites W2048246816 @default.
• W2036718295 cites W2054608358 @default.
• W2036718295 cites W2083371934 @default.
• W2036718295 cites W2085315327 @default.
• W2036718295 cites W2090808827 @default.
• W2036718295 cites W2097950973 @default.
• W2036718295 cites W2116908385 @default.
• W2036718295 cites W2119767517 @default.
• W2036718295 cites W2120240963 @default.
• W2036718295 cites W2127148788 @default.
• W2036718295 cites W2128201302 @default.
• W2036718295 cites W2130173258 @default.
• W2036718295 cites W2130979840 @default.
• W2036718295 cites W2131661253 @default.
• W2036718295 cites W2136899564 @default.
• W2036718295 cites W2164889608 @default.
• W2036718295 cites W2188961409 @default.
• W2036718295 cites W4247938048 @default.
• W2036718295 doi "https://doi.org/10.1158/1055-9965.epi-08-0519" @default.
• W2036718295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18990736" @default.
• W2036718295 hasPublicationYear "2008" @default.
• W2036718295 type Work @default.
• W2036718295 sameAs 2036718295 @default.
• W2036718295 citedByCount "45" @default.
• W2036718295 countsByYear W20367182952012 @default.
• W2036718295 countsByYear W20367182952013 @default.
• W2036718295 countsByYear W20367182952014 @default.
• W2036718295 countsByYear W20367182952015 @default.
• W2036718295 countsByYear W20367182952016 @default.
• W2036718295 countsByYear W20367182952017 @default.
• W2036718295 countsByYear W20367182952018 @default.
• W2036718295 countsByYear W20367182952019 @default.
• W2036718295 countsByYear W20367182952020 @default.
• W2036718295 countsByYear W20367182952021 @default.
• W2036718295 countsByYear W20367182952022 @default.
• W2036718295 countsByYear W20367182952023 @default.
• W2036718295 crossrefType "journal-article" @default.
• W2036718295 hasAuthorship W2036718295A5067257359 @default.
• W2036718295 hasAuthorship W2036718295A5067509213 @default.
• W2036718295 hasConcept C107130276 @default.
• W2036718295 hasConcept C112930515 @default.
• W2036718295 hasConcept C116567970 @default.
• W2036718295 hasConcept C121332964 @default.
• W2036718295 hasConcept C142724271 @default.
• W2036718295 hasConcept C148482608 @default.
• W2036718295 hasConcept C151730666 @default.
• W2036718295 hasConcept C152662350 @default.
• W2036718295 hasConcept C177860879 @default.
• W2036718295 hasConcept C23131810 @default.
• W2036718295 hasConcept C2522767166 @default.
• W2036718295 hasConcept C2779343474 @default.
• W2036718295 hasConcept C41008148 @default.
• W2036718295 hasConcept C535046627 @default.
• W2036718295 hasConcept C60644358 @default.
• W2036718295 hasConcept C62520636 @default.
• W2036718295 hasConcept C64357122 @default.
• W2036718295 hasConcept C70721500 @default.
• W2036718295 hasConcept C71924100 @default.
• W2036718295 hasConcept C86803240 @default.
• W2036718295 hasConceptScore W2036718295C107130276 @default.
• W2036718295 hasConceptScore W2036718295C112930515 @default.
• W2036718295 hasConceptScore W2036718295C116567970 @default.
• W2036718295 hasConceptScore W2036718295C121332964 @default.
• W2036718295 hasConceptScore W2036718295C142724271 @default.
• W2036718295 hasConceptScore W2036718295C148482608 @default.
• W2036718295 hasConceptScore W2036718295C151730666 @default.
• W2036718295 hasConceptScore W2036718295C152662350 @default.
• W2036718295 hasConceptScore W2036718295C177860879 @default.
• W2036718295 hasConceptScore W2036718295C23131810 @default.
• W2036718295 hasConceptScore W2036718295C2522767166 @default.
• W2036718295 hasConceptScore W2036718295C2779343474 @default.
• W2036718295 hasConceptScore W2036718295C41008148 @default.
• W2036718295 hasConceptScore W2036718295C535046627 @default.
• W2036718295 hasConceptScore W2036718295C60644358 @default.
• W2036718295 hasConceptScore W2036718295C62520636 @default.
• W2036718295 hasConceptScore W2036718295C64357122 @default.
• W2036718295 hasConceptScore W2036718295C70721500 @default.
• W2036718295 hasConceptScore W2036718295C71924100 @default.
• W2036718295 hasConceptScore W2036718295C86803240 @default.
• W2036718295 hasIssue "11" @default.

• next