FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036723932> ?p ?o ?g. }

• W2036723932 endingPage "247" @default.
• W2036723932 startingPage "242" @default.
• W2036723932 abstract "Background Irinotecan is highly active against rhabdomyosarcoma (RMS), yet its tolerability and efficacy in combination with radiation is unknown. We examined local control and toxicities in RMS patients treated with radiotherapy (RT) in combination with radiosensitizing agents irinotecan + carboplatin (I + C). Procedure From 11/2003 to 1/2011, 60 patients were enrolled on a pilot phase II protocol with newly diagnosed intermediate- or high-risk RMS at Memorial Sloan-Kettering Cancer Center. Induction therapy consisted of two cycles of I + C followed by three cycles of vincristine, doxorubicin, and cyclophosphamide. At week 13, 47 patients received definitive primary-site RT or post-operative RT with two concurrent cycles of I + C. Median RT dose was 50.4 Gy (range 30.6–50.4 Gy). Radiation-related toxicities were evaluated according to the Common Terminology Criteria for Adverse Events, version 3.0. Results Median age of the cohort was 9 years. With median follow-up of 32 months, 2.5 year actuarial local control was 89%. Among all patients, grades 3 and 4 dermatitis were observed in 11% and 4%, respectively. Among parameningeal, orbit, and other head/neck sites, rates of grades 3 and 4 mucositis were 20% and 10%, respectively. Among abdomen/pelvis sites, 12% developed grade 3 diarrhea and 6% developed grade 3 cystitis. No treatment breaks were necessary. Conclusions Preliminary results of irinotecan and carboplatin administered with concurrent RT in intermediate- and high-risk RMS demonstrated favorable tolerability, efficacy, and local control. Reduced rates of acute grades 3–4 mucositis were observed when compared with historical results. Pediatr Blood Cancer 2013;60:242–247. © 2012 Wiley Periodicals, Inc." @default.
• W2036723932 created "2016-06-24" @default.
• W2036723932 creator A5011598150 @default.
• W2036723932 creator A5074725191 @default.
• W2036723932 creator A5080725919 @default.
• W2036723932 date "2012-05-22" @default.
• W2036723932 modified "2023-10-05" @default.
• W2036723932 title "Concurrent radiation with irinotecan and carboplatin in intermediate- and high-risk rhabdomyosarcoma: A report on toxicity and efficacy from a prospective pilot phase II study" @default.
• W2036723932 cites W1499222173 @default.
• W2036723932 cites W1888038496 @default.
• W2036723932 cites W1935226228 @default.
• W2036723932 cites W1999434056 @default.
• W2036723932 cites W2011909208 @default.
• W2036723932 cites W2012177665 @default.
• W2036723932 cites W2033485414 @default.
• W2036723932 cites W2050746528 @default.
• W2036723932 cites W2059984427 @default.
• W2036723932 cites W2066223656 @default.
• W2036723932 cites W2079091820 @default.
• W2036723932 cites W2099595985 @default.
• W2036723932 cites W2115827778 @default.
• W2036723932 cites W2120060416 @default.
• W2036723932 cites W2123081410 @default.
• W2036723932 cites W2132708985 @default.
• W2036723932 cites W2153544919 @default.
• W2036723932 doi "https://doi.org/10.1002/pbc.24205" @default.
• W2036723932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22619050" @default.
• W2036723932 hasPublicationYear "2012" @default.
• W2036723932 type Work @default.
• W2036723932 sameAs 2036723932 @default.
• W2036723932 citedByCount "22" @default.
• W2036723932 countsByYear W20367239322014 @default.
• W2036723932 countsByYear W20367239322015 @default.
• W2036723932 countsByYear W20367239322016 @default.
• W2036723932 countsByYear W20367239322017 @default.
• W2036723932 countsByYear W20367239322018 @default.
• W2036723932 countsByYear W20367239322019 @default.
• W2036723932 countsByYear W20367239322020 @default.
• W2036723932 countsByYear W20367239322021 @default.
• W2036723932 countsByYear W20367239322023 @default.
• W2036723932 crossrefType "journal-article" @default.
• W2036723932 hasAuthorship W2036723932A5011598150 @default.
• W2036723932 hasAuthorship W2036723932A5074725191 @default.
• W2036723932 hasAuthorship W2036723932A5080725919 @default.
• W2036723932 hasConcept C121608353 @default.
• W2036723932 hasConcept C126322002 @default.
• W2036723932 hasConcept C141071460 @default.
• W2036723932 hasConcept C142724271 @default.
• W2036723932 hasConcept C143998085 @default.
• W2036723932 hasConcept C197934379 @default.
• W2036723932 hasConcept C2776694085 @default.
• W2036723932 hasConcept C2777063308 @default.
• W2036723932 hasConcept C2777793932 @default.
• W2036723932 hasConcept C2778239845 @default.
• W2036723932 hasConcept C2778256501 @default.
• W2036723932 hasConcept C2778375690 @default.
• W2036723932 hasConcept C2778496288 @default.
• W2036723932 hasConcept C2780259306 @default.
• W2036723932 hasConcept C2780844630 @default.
• W2036723932 hasConcept C2781451048 @default.
• W2036723932 hasConcept C509974204 @default.
• W2036723932 hasConcept C526805850 @default.
• W2036723932 hasConcept C71924100 @default.
• W2036723932 hasConceptScore W2036723932C121608353 @default.
• W2036723932 hasConceptScore W2036723932C126322002 @default.
• W2036723932 hasConceptScore W2036723932C141071460 @default.
• W2036723932 hasConceptScore W2036723932C142724271 @default.
• W2036723932 hasConceptScore W2036723932C143998085 @default.
• W2036723932 hasConceptScore W2036723932C197934379 @default.
• W2036723932 hasConceptScore W2036723932C2776694085 @default.
• W2036723932 hasConceptScore W2036723932C2777063308 @default.
• W2036723932 hasConceptScore W2036723932C2777793932 @default.
• W2036723932 hasConceptScore W2036723932C2778239845 @default.
• W2036723932 hasConceptScore W2036723932C2778256501 @default.
• W2036723932 hasConceptScore W2036723932C2778375690 @default.
• W2036723932 hasConceptScore W2036723932C2778496288 @default.
• W2036723932 hasConceptScore W2036723932C2780259306 @default.
• W2036723932 hasConceptScore W2036723932C2780844630 @default.
• W2036723932 hasConceptScore W2036723932C2781451048 @default.
• W2036723932 hasConceptScore W2036723932C509974204 @default.
• W2036723932 hasConceptScore W2036723932C526805850 @default.
• W2036723932 hasConceptScore W2036723932C71924100 @default.
• W2036723932 hasIssue "2" @default.
• W2036723932 hasLocation W20367239321 @default.
• W2036723932 hasLocation W20367239322 @default.
• W2036723932 hasOpenAccess W2036723932 @default.
• W2036723932 hasPrimaryLocation W20367239321 @default.
• W2036723932 hasRelatedWork W2036723932 @default.
• W2036723932 hasRelatedWork W2064900812 @default.
• W2036723932 hasRelatedWork W2079627700 @default.
• W2036723932 hasRelatedWork W2183078339 @default.
• W2036723932 hasRelatedWork W2410596986 @default.
• W2036723932 hasRelatedWork W26919260 @default.
• W2036723932 hasRelatedWork W2739001369 @default.
• W2036723932 hasRelatedWork W2896565415 @default.
• W2036723932 hasRelatedWork W2999983825 @default.
• W2036723932 hasRelatedWork W335556741 @default.
• W2036723932 hasVolume "60" @default.

• next