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• W2036724487 abstract "MicroRNA-153 acts as a prognostic marker in gastric cancer and its role in cell migration and invasion Zhengliang Zhang,1 Jiangli Sun,1 Zhenghai Bai,1 Haijun Li,2 Shicai He,2 Rui Chen,2 Xiangming Che21Department of Emergency, Second Affiliated Hospital of Xi’an Jiaotong University, 2Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of ChinaAbstract: MicroRNA (miRNA)-153 (miR-153) has been considered as a novel tumor-related miRNA and is found to be significantly deregulated in human cancers. In this study, we found that the expression levels of miR-153 were obviously lower in gastric cancer tissues than those in matched adjacent nontumor tissues. Otherwise, miR-153 was expressed at significantly lower levels in aggressive tumor tissues. Clinical association analysis indicated that low expression of miR-153 was prominently correlated with poor prognostic features in gastric cancer. Furthermore, we demonstrated that the low expression of miR-153 was correlated with short 5-year survival of gastric cancer patients. Multivariate Cox regression analysis indicated that miR-153 was an independent prognostic marker in gastric cancer. Our in vitro studies showed that upregulation of miR-153 reduced cell migration and invasion in MKN-45 cells. Meanwhile, downregulation of miR-153 promoted SGC-7901 cell migration and invasion. An inverse correlation between miR-153 and SNAI1 expression was observed in gastric cancer tissues. In addition, upregulation of miR-153 reduced SNAI1 expression and subsequently suppressed epithelial–mesenchymal transition (EMT) with elevated expression of E-cadherin and reduced expression of vimentin in MKN-45 cells. Furthermore, downregulation of miR-153 increased SNAI1 expression and promoted EMT in SGC-7901 cells. In conclusion, miR-153 is an independent prognostic marker for predicting survival of gastric cancer patients and may promote gastric cancer cell migration and invasion, by inhibiting SNAI1-induced EMT.Keywords: miR-153, prognosis, SNAI1, EMT, tumor metastasis" @default.
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• W2036724487 date "2015-02-01" @default.
• W2036724487 modified "2023-10-18" @default.
• W2036724487 title "MicroRNA-153 acts as a prognostic marker in gastric cancer and its role in cell migration and&nbsp;invasion" @default.
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• W2036724487 doi "https://doi.org/10.2147/ott.s78236" @default.
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