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- W2036725325 abstract "SummaryThe intravenous injection of cobalt chloride is accompained by a transent yperglycemic episode and causes rapid selective injury to the alpha cells of the pancreatic islets which can still be observed after 10 days. However, regeneration of the alpha cells startsw by the 6th day. 2. Since repeated cobalt injections each elicit a similr change in the blood sugar level, this is thought not to be due to the alpha cell damage but to an extrapancreatic toxic action of cobalt probably on the liver. 3. Hypoglycemia is not observed in normal rabbits with alpha cell damage, suggesting that the blood sugar homeostasis does not depend on the integrity of these cells. 4. Although a lowering of the blood sugar which is apparently a toxic effect, is observed in alloxan diabetic animals fora few days after repeated cobalt injection, the pre-injection level is regained while alpha cell damage is still present. This is interpreted to signify that the severity of the diabetes of the alloxanized animal is not a resul..." @default.
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- W2036725325 date "1953-03-01" @default.
- W2036725325 modified "2023-09-27" @default.
- W2036725325 title "Alpha Cell Damage and Blood Sugar Changes in Rabbits after Administration of Cobalt." @default.
- W2036725325 doi "https://doi.org/10.3181/00379727-82-20130" @default.
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