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• W2036725433 abstract "Bioassay-guided fractionation of the crude CH2Cl2/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1–3 are potent antitrypanosomal agents with IC50 values of 0.077, 0.032, and 1.33 μM against Trypanosoma brucei brucei, respectively." @default.
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• W2036725433 date "2010-05-01" @default.
• W2036725433 modified "2023-10-10" @default.
• W2036725433 title "Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum" @default.
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• W2036725433 doi "https://doi.org/10.1016/j.tetlet.2010.02.161" @default.
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