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- W2036728539 abstract "The production of nitric oxide (NO) by rat adherent peritoneal cells stimulated with preformed IgE/Dinitrophenyl-BSA (DNP-BSA) complexes and its dependence on the activation of the transcription factor NF-κB were studied. Stimulation with IgE/DNP-BSA complexes at equivalence induced both the production of NO and an increased expression of the inducible isoform of NO synthase (iNOS) protein. Both events were also elicited by a rabbit polyclonal F(ab′)2anti-CD23 cross-reacting with rat CD23, thus suggesting FcϵRII/CD23 antigen as the IgE-binding structure involved in the triggering of the response and ruling out an interaction of the antibody via its Fc portion. Inhibition of redox-sensitive signaling mechanisms by the antioxidant pyrrolidine dithiocarbamate (PDTC) blocked NO production, iNOS expression, and NF-κB activation elicited by both IgE/DNP-BSA complexes and anti-CD23 F(ab′)2, thus suggesting the involvement of NF-κB in the signaling pathway leading to the transcriptional activation of iNOS. These results show the existence in rat peritoneal macrophages of a signaling pathway triggered by CD23 engagement that promotes nuclear translocation of NF-κB and transcriptional activation of the inducible isoform of NO synthase." @default.
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- W2036728539 date "1992-01-01" @default.
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- W2036728539 title "The role of soluble CD23 on normal and leukaemic myeloid precursor cells" @default.
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- W2036728539 doi "https://doi.org/10.1016/s0923-2494(05)80080-x" @default.
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