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- W2036730379 abstract "The pathogenesis of schizophrenia might involve abnormal development of the human brain. Interleukin-1β is a cytokine implicated in the development of the central nervous system and therefore its gene is a candidate gene in schizophrenia. Polymorphisms within the coding sequence and the 3'UTR of the IL1β gene were searched for using PCR-SSCP. Two polymorphisms, 1B-175/1B-173 and 1B-1765/1B-1763 were found in addition to the previously published TaqI site. Furthermore, a mutant was found in codon 106 (exon 5) of the IL1β gene located next to the published polymorphism at the TaqI site and abolishing this site. This novel mutation encodes an Asp in place of an Asn and was only observed in one patient in our French population. Association studies were conducted with the polymorphisms 1B-175/1B-173 and TaqI. There was no allelic or genotypic association between either of the two polymorphisms and schizophrenia. In our population, there is no evidence that the IL1β gene is involved in schizophrenia." @default.
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- W2036730379 date "1997-01-01" @default.
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- W2036730379 title "Detection of two new polymorphic sites in the human interleukin-1β gene" @default.
- W2036730379 doi "https://doi.org/10.1097/00041444-199723000-00002" @default.
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