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- W2036746240 abstract "Little is known regarding the immunobiology of regulatory T (Treg) cells in hematopoietic malignancies, particularly in chronic lymphocytic leukemia (CLL). In the present study, we showed that the frequencies of CD8(+) and CD4(+) Treg cells were significantly increased in progressive as compared with indolent CLL patients and normal subjects. Enriched CD4(+) Treg cells induced a similar level of inhibition in polyclonally activated B cells and effector T cells from CLL patients and normal subjects. Our results suggest that the increase in circulating Treg cells may result in downregulation of tumor-specific immune response, leading to tumor expansion and disease progression." @default.
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- W2036746240 date "2013-01-03" @default.
- W2036746240 modified "2023-10-13" @default.
- W2036746240 title "Increased Frequency of CD8<sup>+</sup>and CD4<sup>+</sup>Regulatory T Cells in Chronic Lymphocytic Leukemia: Association with Disease Progression" @default.
- W2036746240 cites W2044670364 @default.
- W2036746240 doi "https://doi.org/10.3109/07357907.2012.756110" @default.
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