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- W2036746658 abstract "Enhanced sodium-proton exchange may play a role in the pathogenesis of hypertension. Na+-H+ exchange was measured indirectly in platelets as the rate of amiloride-sensitive and sodium-dependent volume gain of cells suspended in sodium-propionate; the cytoplasmic acidification induced by the permeant propionic acid activated the exchanger and the volume changes coupled to Na+ uptake were measured by cell sizing with a Coulter counter and 'Channelyzer'. The test was rapid, simple, and reproducible. 20 normotensives; 8 normotensives with a family history of hypertension; 15 patients with essential hypertension receiving medication; and 7 hypertensives who had not received any antihypertensive drugs were studied. The exchange rate constants of these groups were (mean [SE] in s-1 × 10-3) 13·1 (0·6); 15·5 (0·7); 18·4 (0·9); and 25·6 (2·8), respectively. The differences between hypertensives and normotensives were significant. Measurement of sodium-proton exchange in platelets may help to clarify the pathogenesis of hypertension." @default.
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- W2036746658 date "1987-03-01" @default.
- W2036746658 modified "2023-09-27" @default.
- W2036746658 title "INCREASED PLATELET Na+-H+ EXCHANGE RATES IN ESSENTIAL HYPERTENSION: APPLICATION OF A NOVEL TEST" @default.
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- W2036746658 doi "https://doi.org/10.1016/s0140-6736(87)90176-0" @default.
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