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- W2036751497 abstract "Electronic absorption, emission, and excitation spectra, and fluorescence lifetimes of two H1 antihistamines—tripelennamine and mepyramine—are investigated in detail to ascertain their usefulness as fluorescent probes for ligand binding to G-protein coupled receptors. The photophysical behavior of these compounds in aqueous solution is complex due to the presence of three protonable nitrogens, intramolecular hydrogen bonding, quenching due to the formation of a charge transfer state, and intramolecular fluorescence resonance energy transfer. At physiological pH values, anomalous photophysical behavior is observed: the compounds are found to be in a ground-state equilibrium mixture of two species, one with the alkylamine tail involved in an intramolecular hydrogen bond and a second without such a bond. This internal hydrogen-bonded tail has a profound effect on the ground and excited-state properties of both tripelennamine and mepyramine, which is further elucidated by comparing them to the reference compounds 2-aminopyridine and 2-(N,N-dimethylamino)pyridine." @default.
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- W2036751497 date "2009-04-23" @default.
- W2036751497 modified "2023-09-23" @default.
- W2036751497 title "Anomalous Photophysics of H<sub>1</sub> Antihistamines in Aqueous Solution" @default.
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- W2036751497 doi "https://doi.org/10.1021/jp9005907" @default.
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