FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036760054> ?p ?o ?g. }

• W2036760054 endingPage "377" @default.
• W2036760054 startingPage "369" @default.
• W2036760054 abstract "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired stem-cell disorder associated with intravascular hemolysis and thrombosis. Hemolysis is caused by the hypersensitivity of PNH-red blood cells (RBC) to complement-mediated lysis due to deficiency in the surface glycosyl phosphatidylinositol-anchored antigens, CD55 and CD59. Thrombosis may be related to the platelet tendency to undergo hyperactivation. We previously suggested that hemolysis and thrombosis in other hemolytic anemias are related to oxidative stress. In the present study, we assessed the oxidative status of blood cells in PNH and tested the potential protective effects of antioxidants.Blood samples were obtained from 11 PNH patients and 11 normal control donors. Flow cytometry was used to measure oxidative stress markers in conjunction with the PNH immunophenotype.Results indicated that abnormal, CD55/CD59-negative, RBC, neutrophils, and platelets are under oxidative stress. Their intracellular reactive oxygen species, membrane lipid peroxides, and external phosphatidylserine were higher and their reduced glutathione was lower than CD55/CD59-positive cells of the same patient or cells of normal controls. PNH-RBC were hypersensitive to an oxidative insult (e.g., hydrogen peroxide) and their oxidative status increased following interaction with complement, prior to hemolysis. Antioxidants reduced this hemolysis as well as activation of PNH platelets.We propose that oxidative stress mediates the symptoms of PNH and suggest that antioxidants might be considered as a therapeutic modality." @default.
• W2036760054 created "2016-06-24" @default.
• W2036760054 creator A5015469728 @default.
• W2036760054 creator A5026539617 @default.
• W2036760054 creator A5030400827 @default.
• W2036760054 date "2008-04-01" @default.
• W2036760054 modified "2023-10-17" @default.
• W2036760054 title "Oxidative status of red blood cells, neutrophils, and platelets in paroxysmal nocturnal hemoglobinuria" @default.
• W2036760054 cites W1479789413 @default.
• W2036760054 cites W1974877479 @default.
• W2036760054 cites W1992629946 @default.
• W2036760054 cites W2005712358 @default.
• W2036760054 cites W2008560188 @default.
• W2036760054 cites W2027259889 @default.
• W2036760054 cites W2029549314 @default.
• W2036760054 cites W2033392675 @default.
• W2036760054 cites W2035330181 @default.
• W2036760054 cites W2043251376 @default.
• W2036760054 cites W2044908214 @default.
• W2036760054 cites W2064857315 @default.
• W2036760054 cites W2068579965 @default.
• W2036760054 cites W2074202650 @default.
• W2036760054 cites W2081946053 @default.
• W2036760054 cites W2081978633 @default.
• W2036760054 cites W2083478191 @default.
• W2036760054 cites W2089818502 @default.
• W2036760054 cites W2093544782 @default.
• W2036760054 cites W2097908856 @default.
• W2036760054 cites W2119216872 @default.
• W2036760054 cites W2122416478 @default.
• W2036760054 cites W2123429071 @default.
• W2036760054 cites W2127290864 @default.
• W2036760054 cites W2133538175 @default.
• W2036760054 cites W2147993424 @default.
• W2036760054 cites W2152757679 @default.
• W2036760054 cites W2166154872 @default.
• W2036760054 cites W2198426544 @default.
• W2036760054 cites W2385724378 @default.
• W2036760054 cites W315197452 @default.
• W2036760054 cites W4210963174 @default.
• W2036760054 doi "https://doi.org/10.1016/j.exphem.2007.12.003" @default.
• W2036760054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18261835" @default.
• W2036760054 hasPublicationYear "2008" @default.
• W2036760054 type Work @default.
• W2036760054 sameAs 2036760054 @default.
• W2036760054 citedByCount "41" @default.
• W2036760054 countsByYear W20367600542012 @default.
• W2036760054 countsByYear W20367600542013 @default.
• W2036760054 countsByYear W20367600542014 @default.
• W2036760054 countsByYear W20367600542015 @default.
• W2036760054 countsByYear W20367600542017 @default.
• W2036760054 countsByYear W20367600542018 @default.
• W2036760054 countsByYear W20367600542019 @default.
• W2036760054 countsByYear W20367600542020 @default.
• W2036760054 countsByYear W20367600542021 @default.
• W2036760054 countsByYear W20367600542023 @default.
• W2036760054 crossrefType "journal-article" @default.
• W2036760054 hasAuthorship W2036760054A5015469728 @default.
• W2036760054 hasAuthorship W2036760054A5026539617 @default.
• W2036760054 hasAuthorship W2036760054A5030400827 @default.
• W2036760054 hasBestOaLocation W20367600541 @default.
• W2036760054 hasConcept C111684460 @default.
• W2036760054 hasConcept C126322002 @default.
• W2036760054 hasConcept C134018914 @default.
• W2036760054 hasConcept C184404459 @default.
• W2036760054 hasConcept C185592680 @default.
• W2036760054 hasConcept C203014093 @default.
• W2036760054 hasConcept C2776151105 @default.
• W2036760054 hasConcept C2777346216 @default.
• W2036760054 hasConcept C2778639011 @default.
• W2036760054 hasConcept C2779902561 @default.
• W2036760054 hasConcept C71924100 @default.
• W2036760054 hasConcept C8891405 @default.
• W2036760054 hasConcept C89560881 @default.
• W2036760054 hasConceptScore W2036760054C111684460 @default.
• W2036760054 hasConceptScore W2036760054C126322002 @default.
• W2036760054 hasConceptScore W2036760054C134018914 @default.
• W2036760054 hasConceptScore W2036760054C184404459 @default.
• W2036760054 hasConceptScore W2036760054C185592680 @default.
• W2036760054 hasConceptScore W2036760054C203014093 @default.
• W2036760054 hasConceptScore W2036760054C2776151105 @default.
• W2036760054 hasConceptScore W2036760054C2777346216 @default.
• W2036760054 hasConceptScore W2036760054C2778639011 @default.
• W2036760054 hasConceptScore W2036760054C2779902561 @default.
• W2036760054 hasConceptScore W2036760054C71924100 @default.
• W2036760054 hasConceptScore W2036760054C8891405 @default.
• W2036760054 hasConceptScore W2036760054C89560881 @default.
• W2036760054 hasIssue "4" @default.
• W2036760054 hasLocation W20367600541 @default.
• W2036760054 hasLocation W20367600542 @default.
• W2036760054 hasOpenAccess W2036760054 @default.
• W2036760054 hasPrimaryLocation W20367600541 @default.
• W2036760054 hasRelatedWork W1967108650 @default.
• W2036760054 hasRelatedWork W2024562413 @default.
• W2036760054 hasRelatedWork W2070729260 @default.
• W2036760054 hasRelatedWork W2081653014 @default.
• W2036760054 hasRelatedWork W2387270727 @default.
• W2036760054 hasRelatedWork W2406271018 @default.

• next