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- W2036760209 abstract "Purpose of review Epidemiological studies consistently link moderate alcohol use with a lower risk of cardiovascular disease, but a number of important issues remain controversial. These include the putative impact of non-alcoholic constituents of some alcoholic beverages, the role of genetic factors, potential mechanisms for this association, and confirmation of the relationship in experimental models. Recent findings Although high-density lipoprotein cholesterol (HDL-C) is considered the primary mediator of the cardiovascular effects of moderate drinking, recent evidence has shown the alcohol-HDL-C relation is not linear beyond the range of moderate drinking. Moderate alcohol use also has important inverse relations with inflammatory factors. Some, but not all, animal models confirm the anti-atherogenic effects of ethanol and highlight inflammatory factors as one possible mechanism. The non-alcoholic constituents of red wine also have anti-atherogenic and perhaps even life-extending properties in vitro, but their relevance to humans remains uncertain. Genetic variants of the apolipoprotein E and interleukin 6 genes in humans may modify how alcohol influences atherosclerosis, further emphasizing the importance of HDL-C and inflammatory factors as mediators. Summary The robust relationship between moderate drinking and lower risk of cardiovascular disease remains an intriguing area of investigation. Clarifying potential gene-environment interactions and translational research into uses for non-alcoholic components will be important areas for future investigation." @default.
- W2036760209 created "2016-06-24" @default.
- W2036760209 creator A5041104244 @default.
- W2036760209 creator A5091194975 @default.
- W2036760209 date "2004-12-01" @default.
- W2036760209 modified "2023-10-15" @default.
- W2036760209 title "An update on alcohol and atherosclerosis" @default.
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- W2036760209 doi "https://doi.org/10.1097/00041433-200412000-00008" @default.
- W2036760209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15529027" @default.
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