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- W2036763905 abstract "Cells such as fibroblasts and endothelial cells migrate through the coordinated responses of discrete integrin-containing focal adhesions and complexes. In contrast, little is known about the organization of integrins on the highly motile T lymphocyte. We have investigated the distribution, activity, and cytoskeletal linkage of the integrin lymphocyte function associated antigen-1 (LFA-1) on human T lymphocytes migrating on endothelial cells and on ligand intercellular adhesion molecule-1 (ICAM-1). The pattern of total LFA-1 varies from low expression in the lamellipodia to high expression in the uropod. However, high affinity, clustered LFA-1 is restricted to a mid-cell zone that remains stable over time and over a range of ICAM-1 densities. Talin is essential for the stability and formation of the LFA-1 zone. Disruption of the talin-integrin link leads to loss of zone integrity and a substantial decrease in speed of migration on ICAM-1. This adhesive structure, which differs from the previously described integrin-containing attachments displayed by many other cell types, we have termed the focal zone." @default.
- W2036763905 created "2016-06-24" @default.
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- W2036763905 date "2005-06-27" @default.
- W2036763905 modified "2023-09-30" @default.
- W2036763905 title "A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes" @default.
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- W2036763905 doi "https://doi.org/10.1083/jcb.200412032" @default.
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