Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036765536> ?p ?o ?g. }
- W2036765536 endingPage "e98606" @default.
- W2036765536 startingPage "e98606" @default.
- W2036765536 abstract "Immature dendritic cells (DCs) maintain a highly dynamic pool of recycling MHCII that promotes sampling of environmental antigens for presentation to T helper cells. However, the molecular basis of MHCII recycling and the cellular machinery that orchestrates MHCII trafficking are incompletely understood. Using a mouse model we show that WASH, an actin regulatory protein that facilitates retromer function, is essential for MHCII recycling and efficient priming of T helper cells. We further demonstrate that WASH deficiency results in impaired MHCII surface levels, recycling, and an accumulation of polyubiquitinated MHCII complexes, which are subsequently slated for premature lysosomal degradation. Consequently, conditional deletion of the Wash gene in DCs impairs priming of both conventional and autoimmune T helper cells in vivo and attenuates disease progression in a model of experimental autoimmune encephalitis (EAE). Thus, we identify a novel mechanism in which DCs employ the evolutionarily conserved WASH and retromer complex for MHCII recycling in order to regulate T helper cell priming." @default.
- W2036765536 created "2016-06-24" @default.
- W2036765536 creator A5002276285 @default.
- W2036765536 creator A5020581774 @default.
- W2036765536 creator A5023257071 @default.
- W2036765536 creator A5026016872 @default.
- W2036765536 creator A5038115458 @default.
- W2036765536 creator A5069601093 @default.
- W2036765536 creator A5070669260 @default.
- W2036765536 creator A5080426319 @default.
- W2036765536 creator A5086695530 @default.
- W2036765536 date "2014-06-02" @default.
- W2036765536 modified "2023-09-30" @default.
- W2036765536 title "Dendritic Cells Utilize the Evolutionarily Conserved WASH and Retromer Complexes to Promote MHCII Recycling and Helper T Cell Priming" @default.
- W2036765536 cites W1483922594 @default.
- W2036765536 cites W1507598785 @default.
- W2036765536 cites W1595293335 @default.
- W2036765536 cites W1967904525 @default.
- W2036765536 cites W1968578345 @default.
- W2036765536 cites W1972557751 @default.
- W2036765536 cites W1980269923 @default.
- W2036765536 cites W1982307380 @default.
- W2036765536 cites W1991752238 @default.
- W2036765536 cites W1993923133 @default.
- W2036765536 cites W1999056400 @default.
- W2036765536 cites W2003272127 @default.
- W2036765536 cites W2010946325 @default.
- W2036765536 cites W2011520932 @default.
- W2036765536 cites W2030369847 @default.
- W2036765536 cites W2032793177 @default.
- W2036765536 cites W2036062404 @default.
- W2036765536 cites W2038642995 @default.
- W2036765536 cites W2048777851 @default.
- W2036765536 cites W2051731494 @default.
- W2036765536 cites W2055631483 @default.
- W2036765536 cites W2061111237 @default.
- W2036765536 cites W2081287274 @default.
- W2036765536 cites W2081664488 @default.
- W2036765536 cites W2094028293 @default.
- W2036765536 cites W2094539919 @default.
- W2036765536 cites W2095751049 @default.
- W2036765536 cites W2099472310 @default.
- W2036765536 cites W2103090750 @default.
- W2036765536 cites W2104095808 @default.
- W2036765536 cites W2109854904 @default.
- W2036765536 cites W2111695773 @default.
- W2036765536 cites W2112276726 @default.
- W2036765536 cites W2113669648 @default.
- W2036765536 cites W2116582697 @default.
- W2036765536 cites W2122791726 @default.
- W2036765536 cites W2125958204 @default.
- W2036765536 cites W2127404676 @default.
- W2036765536 cites W2129580137 @default.
- W2036765536 cites W2129912620 @default.
- W2036765536 cites W2137670912 @default.
- W2036765536 cites W2141859364 @default.
- W2036765536 cites W2142424369 @default.
- W2036765536 cites W2145670054 @default.
- W2036765536 cites W4243195227 @default.
- W2036765536 cites W4313333710 @default.
- W2036765536 doi "https://doi.org/10.1371/journal.pone.0098606" @default.
- W2036765536 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4041763" @default.
- W2036765536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24886983" @default.
- W2036765536 hasPublicationYear "2014" @default.
- W2036765536 type Work @default.
- W2036765536 sameAs 2036765536 @default.
- W2036765536 citedByCount "14" @default.
- W2036765536 countsByYear W20367655362014 @default.
- W2036765536 countsByYear W20367655362016 @default.
- W2036765536 countsByYear W20367655362017 @default.
- W2036765536 countsByYear W20367655362018 @default.
- W2036765536 countsByYear W20367655362019 @default.
- W2036765536 countsByYear W20367655362020 @default.
- W2036765536 countsByYear W20367655362022 @default.
- W2036765536 countsByYear W20367655362023 @default.
- W2036765536 crossrefType "journal-article" @default.
- W2036765536 hasAuthorship W2036765536A5002276285 @default.
- W2036765536 hasAuthorship W2036765536A5020581774 @default.
- W2036765536 hasAuthorship W2036765536A5023257071 @default.
- W2036765536 hasAuthorship W2036765536A5026016872 @default.
- W2036765536 hasAuthorship W2036765536A5038115458 @default.
- W2036765536 hasAuthorship W2036765536A5069601093 @default.
- W2036765536 hasAuthorship W2036765536A5070669260 @default.
- W2036765536 hasAuthorship W2036765536A5080426319 @default.
- W2036765536 hasAuthorship W2036765536A5086695530 @default.
- W2036765536 hasBestOaLocation W20367655361 @default.
- W2036765536 hasConcept C100701293 @default.
- W2036765536 hasConcept C104317684 @default.
- W2036765536 hasConcept C127716648 @default.
- W2036765536 hasConcept C147483822 @default.
- W2036765536 hasConcept C203014093 @default.
- W2036765536 hasConcept C2776090121 @default.
- W2036765536 hasConcept C2778170410 @default.
- W2036765536 hasConcept C2779919695 @default.
- W2036765536 hasConcept C54355233 @default.
- W2036765536 hasConcept C59822182 @default.
- W2036765536 hasConcept C67662055 @default.
- W2036765536 hasConcept C81444415 @default.