FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036766668> ?p ?o ?g. }

• W2036766668 endingPage "51" @default.
• W2036766668 startingPage "44" @default.
• W2036766668 abstract "The genotoxic effects of 2-acetylaminofluorene (AAF) alone cannot explain the formation of rat liver tumors. It has been proposed that mitochondrial effects are associated with its tumor-promoting properties. These mitochondrial effects are thought to trigger apoptosis and regenerative proliferation, which alters the liver lobule in a cirrhosis-like manner. A situation is generated which favors the growth of initiated cells. To test this sequence of events, the dose dependence of early effects with time was studied. Male Wistar rats received 50, 100, 200, 400, or 800 ppm AAF in the diet and the following endpoints were analyzed at 2, 4, 8, and 16 weeks of feeding: apoptotic cell death, cell proliferation, GST-P-positive foci (placental form of glutathione S-transferase), and morphological alterations. Hydrolyzable hemoglobin adducts were used as a dosimeter for metabolic activation after 2 weeks of feeding. The hemoglobin adduct levels increased linearly with dose. With the conventional carcinogenic concentration of 200-ppm AAF in the diet, the number of apoptoses increased first, predominantly in the periportal area (2 weeks). Cell proliferation followed with some delay (4 weeks). This reflects regenerative tissue response and not the growth of initiated cells, because the number of enzyme-altered foci was still extremely low at that time. Foci developed only later when the morphology had changed. With 50 ppm AAF in the diet, a no-effect level had not been reached for any of the endpoints, but foci developed much more gradually than with higher doses. Unexpectedly, the proliferative response stabilized at 8 weeks with a labeling index of 12–17, with all AAF concentrations. The observed sequence of events supports the hypothesis. It is concluded that (1) The proliferation of initiated cells—defined as promotable cells—is largely determined by the cellular environment, such as morphologically altered liver. (2) The morphological alterations in rat liver result from imperfect regeneration from toxic effects. (3) Imperfect regeneration results from limitations in the possibilities to adapt to chemical stress. (4) If these limits are overwhelmed and morphology has changed to a certain extent, preneoplastic foci develop; this occurs much faster, at least, than without these changes." @default.
• W2036766668 created "2016-06-24" @default.
• W2036766668 creator A5047437739 @default.
• W2036766668 date "2000-05-01" @default.
• W2036766668 modified "2023-09-25" @default.
• W2036766668 title "Dose Response of Early Effects Related to Tumor Promotion of 2-Acetylaminofluorene" @default.
• W2036766668 cites W1595520662 @default.
• W2036766668 cites W1609366599 @default.
• W2036766668 cites W1898775242 @default.
• W2036766668 cites W1977285018 @default.
• W2036766668 cites W1979015193 @default.
• W2036766668 cites W1980100516 @default.
• W2036766668 cites W1993518407 @default.
• W2036766668 cites W1996225606 @default.
• W2036766668 cites W2000839536 @default.
• W2036766668 cites W2003730105 @default.
• W2036766668 cites W2004471735 @default.
• W2036766668 cites W2010121081 @default.
• W2036766668 cites W2061431574 @default.
• W2036766668 cites W2077303010 @default.
• W2036766668 cites W2079883402 @default.
• W2036766668 cites W2084929175 @default.
• W2036766668 cites W2138302361 @default.
• W2036766668 cites W2157009828 @default.
• W2036766668 cites W2418900771 @default.
• W2036766668 doi "https://doi.org/10.1093/toxsci/55.1.44" @default.
• W2036766668 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10788558" @default.
• W2036766668 hasPublicationYear "2000" @default.
• W2036766668 type Work @default.
• W2036766668 sameAs 2036766668 @default.
• W2036766668 citedByCount "25" @default.
• W2036766668 countsByYear W20367666682012 @default.
• W2036766668 countsByYear W20367666682016 @default.
• W2036766668 countsByYear W20367666682018 @default.
• W2036766668 countsByYear W20367666682020 @default.
• W2036766668 crossrefType "journal-article" @default.
• W2036766668 hasAuthorship W2036766668A5047437739 @default.
• W2036766668 hasConcept C114246631 @default.
• W2036766668 hasConcept C121608353 @default.
• W2036766668 hasConcept C126322002 @default.
• W2036766668 hasConcept C134018914 @default.
• W2036766668 hasConcept C16685009 @default.
• W2036766668 hasConcept C181199279 @default.
• W2036766668 hasConcept C185592680 @default.
• W2036766668 hasConcept C190283241 @default.
• W2036766668 hasConcept C2778287671 @default.
• W2036766668 hasConcept C2779838395 @default.
• W2036766668 hasConcept C31573885 @default.
• W2036766668 hasConcept C502942594 @default.
• W2036766668 hasConcept C55493867 @default.
• W2036766668 hasConcept C555283112 @default.
• W2036766668 hasConcept C57322979 @default.
• W2036766668 hasConcept C62112901 @default.
• W2036766668 hasConcept C71924100 @default.
• W2036766668 hasConcept C86803240 @default.
• W2036766668 hasConcept C87644729 @default.
• W2036766668 hasConceptScore W2036766668C114246631 @default.
• W2036766668 hasConceptScore W2036766668C121608353 @default.
• W2036766668 hasConceptScore W2036766668C126322002 @default.
• W2036766668 hasConceptScore W2036766668C134018914 @default.
• W2036766668 hasConceptScore W2036766668C16685009 @default.
• W2036766668 hasConceptScore W2036766668C181199279 @default.
• W2036766668 hasConceptScore W2036766668C185592680 @default.
• W2036766668 hasConceptScore W2036766668C190283241 @default.
• W2036766668 hasConceptScore W2036766668C2778287671 @default.
• W2036766668 hasConceptScore W2036766668C2779838395 @default.
• W2036766668 hasConceptScore W2036766668C31573885 @default.
• W2036766668 hasConceptScore W2036766668C502942594 @default.
• W2036766668 hasConceptScore W2036766668C55493867 @default.
• W2036766668 hasConceptScore W2036766668C555283112 @default.
• W2036766668 hasConceptScore W2036766668C57322979 @default.
• W2036766668 hasConceptScore W2036766668C62112901 @default.
• W2036766668 hasConceptScore W2036766668C71924100 @default.
• W2036766668 hasConceptScore W2036766668C86803240 @default.
• W2036766668 hasConceptScore W2036766668C87644729 @default.
• W2036766668 hasIssue "1" @default.
• W2036766668 hasLocation W20367666681 @default.
• W2036766668 hasLocation W20367666682 @default.
• W2036766668 hasOpenAccess W2036766668 @default.
• W2036766668 hasPrimaryLocation W20367666681 @default.
• W2036766668 hasRelatedWork W1980100516 @default.
• W2036766668 hasRelatedWork W1988931433 @default.
• W2036766668 hasRelatedWork W1992826282 @default.
• W2036766668 hasRelatedWork W2032050315 @default.
• W2036766668 hasRelatedWork W2070291783 @default.
• W2036766668 hasRelatedWork W2092628825 @default.
• W2036766668 hasRelatedWork W2102444982 @default.
• W2036766668 hasRelatedWork W2380278248 @default.
• W2036766668 hasRelatedWork W4252235959 @default.
• W2036766668 hasRelatedWork W4302405763 @default.
• W2036766668 hasVolume "55" @default.
• W2036766668 isParatext "false" @default.
• W2036766668 isRetracted "false" @default.
• W2036766668 magId "2036766668" @default.
• W2036766668 workType "article" @default.