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• W2036769788 abstract "In the Betaseron/Betaferon in Newly Emerging Multiple Sclerosis for Initial Treatment (BENEFIT) study, interferon beta-1b delayed conversion to multiple sclerosis in patients with a first clinical event and at least 2 clinically silent brain magnetic resonance imaging (MRI) lesions.To examine detailed MRI findings from the first 2 years of this trial.Double-blind, placebo-controlled, randomized, parallel-group, multicenter, phase 3 study.Ninety-eight centers worldwide.A total of 404 individuals with a first demyelinating event suggestive of multiple sclerosis.Patients were randomized to receive interferon beta-1b, 250 microg subcutaneously every other day, or placebo. After 24 months of treatment or on conversion to clinically definite multiple sclerosis, open-label interferon beta-1b treatment was offered.Reported MRI data from patients completing 2 years of follow-up.Data were analyzed from 248 patients taking interferon beta-1b and 156 taking placebo. Across 2 years the cumulative number of newly active lesions was lower in patients receiving interferon beta-1b vs placebo (median, 2.0 vs 5.0 [reduction of 60%]; P < .001). This corresponded to lower cumulative numbers of new T2 lesions (median, 1.0 vs 3.0 [reduction of 66%]; P < .001) and new gadolinium-enhancing lesions (median, 0.0 vs 1.0; P < .001) in patients receiving interferon beta-1b vs placebo. From screening to month 24, T2 lesion volume decreased and was more pronounced in patients receiving interferon beta-1b (P = .02).Interferon beta-1b treatment had a robust effect on MRI measures, supporting its value as an early intervention in this patient group. This effect was maintained despite including patients who switched from placebo to interferon beta-1b in the active treatment group. Trial Registration clinicaltrials.gov Identifier: NCT00185211." @default.
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• W2036769788 date "2007-09-01" @default.
• W2036769788 modified "2023-10-18" @default.
• W2036769788 title "Magnetic Resonance Imaging Effects of Interferon Beta-1b in the BENEFIT Study" @default.
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• W2036769788 doi "https://doi.org/10.1001/archneur.64.9.1292" @default.
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