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• W2036773446 startingPage "16993" @default.
• W2036773446 abstract "Significance We present a unique study of a liver-induced systemic tolerance using an intact virus, other than a single protein component-induced liver-persistent model. Liver-educated regulatory cells migrate into peripheral sites and mediate the systemic tolerance. Kupffer cells induce the generation of type 1-like regulatory cells in an IL-10–dependent manner. A possible role of type 1-like regulatory cells in suppressing germinal center formation via secreting IL-10 is demonstrated. We observed that a “regulatory cell-based” tolerizing mechanism, rather than a “clonal deletion” mechanism, provides the possibility of reversing the tolerance by immunotherapeutic approaches." @default.
• W2036773446 created "2016-06-24" @default.
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• W2036773446 date "2013-10-02" @default.
• W2036773446 modified "2023-09-26" @default.
• W2036773446 title "Liver type I regulatory T cells suppress germinal center formation in HBV-tolerant mice" @default.
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• W2036773446 doi "https://doi.org/10.1073/pnas.1306437110" @default.
• W2036773446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3801062" @default.
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