FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036778868> ?p ?o ?g. }

• W2036778868 endingPage "401" @default.
• W2036778868 startingPage "395" @default.
• W2036778868 abstract "We recently proposed an S-1 combined with oxaliplatin (SOXL) regimen, a combination treatment consisting of oral metronomic S-1 dosing and intravenous administration of oxaliplatin (l-OHP) containing PEGylated liposomes, which showed potent antitumor activity in vivo. PEGylated liposomes induce what is referred to as the “accelerated blood clearance (ABC) phenomenon” upon repeated administration and consequently lose their long-circulating characteristics. This phenomenon seems to pose an impediment for the clinical application and use of PEGylated liposomal formulations. In the present study, l-OHP-containing PEGylated liposomes in the SOXL regimen significantly attenuated the ABC phenomenon in a dose-dependent manner through suppression of the anti-PEG IgM response, which allowed an enhanced hepatic uptake of subsequently injected test PEGylated liposomes. In tumor-bearing mice, the abrogation of the ABC phenomenon restored intratumor accumulation of subsequently injected PEGylated liposomes. Consequently, the therapeutic efficacy of the SOXL regimen over the combination of the free form of the drugs was credited not only with the selective delivery of drugs to the tumor tissue but also with ensuring an adequate accumulation of subsequent doses within the tumor tissue. The SOXL regimen we proposed may hold promise as a safe and effective treatment regimen for advanced colorectal cancer." @default.
• W2036778868 created "2016-06-24" @default.
• W2036778868 creator A5016820951 @default.
• W2036778868 creator A5060557304 @default.
• W2036778868 creator A5067200334 @default.
• W2036778868 creator A5088519518 @default.
• W2036778868 date "2013-01-01" @default.
• W2036778868 modified "2023-09-27" @default.
• W2036778868 title "Abrogation of the accelerated blood clearance phenomenon by SOXL regimen: Promise for clinical application" @default.
• W2036778868 cites W1603870224 @default.
• W2036778868 cites W1796518311 @default.
• W2036778868 cites W1973824708 @default.
• W2036778868 cites W2011891975 @default.
• W2036778868 cites W2020681334 @default.
• W2036778868 cites W2023241123 @default.
• W2036778868 cites W2024414263 @default.
• W2036778868 cites W2034332201 @default.
• W2036778868 cites W2038787775 @default.
• W2036778868 cites W2044618657 @default.
• W2036778868 cites W2045110119 @default.
• W2036778868 cites W2045190720 @default.
• W2036778868 cites W2065902356 @default.
• W2036778868 cites W2083843762 @default.
• W2036778868 cites W2086856055 @default.
• W2036778868 cites W2087167636 @default.
• W2036778868 cites W2089738255 @default.
• W2036778868 cites W2095570105 @default.
• W2036778868 cites W2096194733 @default.
• W2036778868 cites W2098749704 @default.
• W2036778868 cites W2102037532 @default.
• W2036778868 cites W2123133140 @default.
• W2036778868 cites W2128403792 @default.
• W2036778868 cites W2130211871 @default.
• W2036778868 cites W2131496779 @default.
• W2036778868 cites W2133438879 @default.
• W2036778868 cites W2137119070 @default.
• W2036778868 cites W2138644506 @default.
• W2036778868 cites W2141170383 @default.
• W2036778868 cites W2151548176 @default.
• W2036778868 cites W2151747207 @default.
• W2036778868 cites W2161322092 @default.
• W2036778868 cites W4243588803 @default.
• W2036778868 cites W4252472300 @default.
• W2036778868 doi "https://doi.org/10.1016/j.ijpharm.2012.11.015" @default.
• W2036778868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23174409" @default.
• W2036778868 hasPublicationYear "2013" @default.
• W2036778868 type Work @default.
• W2036778868 sameAs 2036778868 @default.
• W2036778868 citedByCount "31" @default.
• W2036778868 countsByYear W20367788682013 @default.
• W2036778868 countsByYear W20367788682014 @default.
• W2036778868 countsByYear W20367788682015 @default.
• W2036778868 countsByYear W20367788682017 @default.
• W2036778868 countsByYear W20367788682018 @default.
• W2036778868 countsByYear W20367788682019 @default.
• W2036778868 countsByYear W20367788682020 @default.
• W2036778868 countsByYear W20367788682021 @default.
• W2036778868 countsByYear W20367788682022 @default.
• W2036778868 countsByYear W20367788682023 @default.
• W2036778868 crossrefType "journal-article" @default.
• W2036778868 hasAuthorship W2036778868A5016820951 @default.
• W2036778868 hasAuthorship W2036778868A5060557304 @default.
• W2036778868 hasAuthorship W2036778868A5067200334 @default.
• W2036778868 hasAuthorship W2036778868A5088519518 @default.
• W2036778868 hasConcept C112705442 @default.
• W2036778868 hasConcept C121608353 @default.
• W2036778868 hasConcept C126322002 @default.
• W2036778868 hasConcept C185154212 @default.
• W2036778868 hasConcept C185592680 @default.
• W2036778868 hasConcept C2780962732 @default.
• W2036778868 hasConcept C2781413609 @default.
• W2036778868 hasConcept C526805850 @default.
• W2036778868 hasConcept C55493867 @default.
• W2036778868 hasConcept C71924100 @default.
• W2036778868 hasConcept C98274493 @default.
• W2036778868 hasConceptScore W2036778868C112705442 @default.
• W2036778868 hasConceptScore W2036778868C121608353 @default.
• W2036778868 hasConceptScore W2036778868C126322002 @default.
• W2036778868 hasConceptScore W2036778868C185154212 @default.
• W2036778868 hasConceptScore W2036778868C185592680 @default.
• W2036778868 hasConceptScore W2036778868C2780962732 @default.
• W2036778868 hasConceptScore W2036778868C2781413609 @default.
• W2036778868 hasConceptScore W2036778868C526805850 @default.
• W2036778868 hasConceptScore W2036778868C55493867 @default.
• W2036778868 hasConceptScore W2036778868C71924100 @default.
• W2036778868 hasConceptScore W2036778868C98274493 @default.
• W2036778868 hasFunder F4320320912 @default.
• W2036778868 hasIssue "1-2" @default.
• W2036778868 hasLocation W20367788681 @default.
• W2036778868 hasLocation W20367788682 @default.
• W2036778868 hasOpenAccess W2036778868 @default.
• W2036778868 hasPrimaryLocation W20367788681 @default.
• W2036778868 hasRelatedWork W1977087300 @default.
• W2036778868 hasRelatedWork W2032943933 @default.
• W2036778868 hasRelatedWork W2059353851 @default.
• W2036778868 hasRelatedWork W2097980094 @default.
• W2036778868 hasRelatedWork W2169309865 @default.
• W2036778868 hasRelatedWork W2377502742 @default.

• next