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- W2036784857 abstract "To establish rate of pregnancy loss following genetic amniocentesis. Pregnancy loss rate after 3112 consecutive genetic amniocenteses, were compared with spontaneous pregnancy loss rate in 2710 patients undergoing first trimester screening (NT or sequential). 98% follow up was obtained in amniocentesis group and 97.5% in control group. Special methods were used to maximize outcome information using hospital data, genetic, laboratory and ultrasound records. Patients with no follow up data were subject to targeted search using private physician records, industry records and direct interviews with patients. In patients who relocated to another geographic area, “people search,” “people finder” and other public search facilities were used to locate them. Control group consisted of patients undergoing first trimester screening, NT, sequential. Pregnancy loss rates following amniocentesis were compared between the groups. 3118 patients underwent genetic amniocentesis between January 2003 and Dec 2007. 2944 (98%) data regarding pregnancy outcome were obtained. In only 72 (2%) no patient information was obtained. Similarly, 98% of the control group had complete follow up. Of 2584 (83%) of subjects with complete records readily available 13 (0.4%) had spontaneous pregnancy losses following amniocentesis. Of 462 (15%) of patients with initially no follow up records of pregnancy outcome, the targeted data search identified 19 (4%) with spontaneous pregnancy losses following amniocentesis. Overall pregnancy loss following genetic amniocentesis was 1.0%. Control group had complete follow up in 2644 (97.5%) with 20 spontaneous pregnancy losses (0.7%) resulting in pregnancy loss attributable to amniocentesis of 0.3%. Our data suggests that pregnancy loss following genetic amniocentesis remains significant at 0.3% and is more accurately assessed when complete follow up is available." @default.
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- W2036784857 date "2009-09-01" @default.
- W2036784857 modified "2023-09-27" @default.
- W2036784857 title "OP31.02: Pregnancy loss following genetic amniocentesis" @default.
- W2036784857 doi "https://doi.org/10.1002/uog.6960" @default.
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