Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036799135> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2036799135 endingPage "237" @default.
- W2036799135 startingPage "233" @default.
- W2036799135 abstract "We examined the effects of pretreatment with phenobarbital and tricresylphosphates, TOCP and TCP, on the metabolism and toxicity of procaine in rats. A single administration of procaine at a dose of 250 mg/kg intraperitoneally to adult rats caused convulsion, however, phenobarbital (80 mg/kg intraperitoneally daily, 4 days) pretreatment protected against the toxicity or procaine. In contrast, pretreatment of rats with TOCP (10 mg/kg per os) or TCP (10 mg/kg per os) revealed a higher incidence of toxicity as compared to control rats. Mortality in procaine-treated rats was significantly decreased with phenobarbital-pretreatment and, conversely, increased with TOCP and TCP. Paralysis, convulsion and death were induced at the brain level of procaine of 0.303 +/- 0.025, 0.480 +/- 0.026 and 0.565 +/- 0.018 mumole/g brain wet weight, respectively. Toxic effects of procaine were, therefore, concluded to be due to the accumulation of the drug in the brain." @default.
- W2036799135 created "2016-06-24" @default.
- W2036799135 creator A5050766720 @default.
- W2036799135 creator A5058096583 @default.
- W2036799135 date "1977-01-01" @default.
- W2036799135 modified "2023-09-23" @default.
- W2036799135 title "Effect of Pretreatment with Tricresylphosphates and Phenobarbital on the Metabolism and Toxicity of Procaine in Rats" @default.
- W2036799135 doi "https://doi.org/10.1254/jjp.27.233" @default.
- W2036799135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/301955" @default.
- W2036799135 hasPublicationYear "1977" @default.
- W2036799135 type Work @default.
- W2036799135 sameAs 2036799135 @default.
- W2036799135 citedByCount "16" @default.
- W2036799135 crossrefType "journal-article" @default.
- W2036799135 hasAuthorship W2036799135A5050766720 @default.
- W2036799135 hasAuthorship W2036799135A5058096583 @default.
- W2036799135 hasBestOaLocation W20367991351 @default.
- W2036799135 hasConcept C118552586 @default.
- W2036799135 hasConcept C178790620 @default.
- W2036799135 hasConcept C185592680 @default.
- W2036799135 hasConcept C2777010014 @default.
- W2036799135 hasConcept C2778186239 @default.
- W2036799135 hasConcept C2778793413 @default.
- W2036799135 hasConcept C2779828710 @default.
- W2036799135 hasConcept C29730261 @default.
- W2036799135 hasConcept C42219234 @default.
- W2036799135 hasConcept C55493867 @default.
- W2036799135 hasConcept C62231903 @default.
- W2036799135 hasConcept C71924100 @default.
- W2036799135 hasConcept C98274493 @default.
- W2036799135 hasConceptScore W2036799135C118552586 @default.
- W2036799135 hasConceptScore W2036799135C178790620 @default.
- W2036799135 hasConceptScore W2036799135C185592680 @default.
- W2036799135 hasConceptScore W2036799135C2777010014 @default.
- W2036799135 hasConceptScore W2036799135C2778186239 @default.
- W2036799135 hasConceptScore W2036799135C2778793413 @default.
- W2036799135 hasConceptScore W2036799135C2779828710 @default.
- W2036799135 hasConceptScore W2036799135C29730261 @default.
- W2036799135 hasConceptScore W2036799135C42219234 @default.
- W2036799135 hasConceptScore W2036799135C55493867 @default.
- W2036799135 hasConceptScore W2036799135C62231903 @default.
- W2036799135 hasConceptScore W2036799135C71924100 @default.
- W2036799135 hasConceptScore W2036799135C98274493 @default.
- W2036799135 hasIssue "2" @default.
- W2036799135 hasLocation W20367991351 @default.
- W2036799135 hasLocation W20367991352 @default.
- W2036799135 hasOpenAccess W2036799135 @default.
- W2036799135 hasPrimaryLocation W20367991351 @default.
- W2036799135 hasRelatedWork W1984142064 @default.
- W2036799135 hasRelatedWork W2008999951 @default.
- W2036799135 hasRelatedWork W2013836009 @default.
- W2036799135 hasRelatedWork W2031134811 @default.
- W2036799135 hasRelatedWork W2036799135 @default.
- W2036799135 hasRelatedWork W2066109785 @default.
- W2036799135 hasRelatedWork W2160021379 @default.
- W2036799135 hasRelatedWork W2410964138 @default.
- W2036799135 hasRelatedWork W2980487051 @default.
- W2036799135 hasRelatedWork W2464624502 @default.
- W2036799135 hasVolume "27" @default.
- W2036799135 isParatext "false" @default.
- W2036799135 isRetracted "false" @default.
- W2036799135 magId "2036799135" @default.
- W2036799135 workType "article" @default.