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• W2036806870 abstract "The expression of activation-induced cytidine deaminase (AID) is prerequisite to a trifecta of key molecular events in B cells: class-switch recombination and somatic hypermutation in humans and mice and gene conversion in chickens. Although this critically important enzyme shares common sequence motifs with apolipoprotein B mRNA-editing enzyme, and exhibits deaminase activity on free deoxycytidine in solution, it has not been shown to act on either RNA or DNA. Recent mutagenesis data in Escherichia coli suggest that AID may deaminate dC on DNA, but its putative biochemical activities on either DNA or RNA remained a mystery. Here, we show that AID catalyzes deamination of dC residues on single-stranded DNA in vitro but not on double-stranded DNA, RNA-DNA hybrids, or RNA. Remarkably, it has no measurable deaminase activity on single-stranded DNA unless pretreated with RNase to remove inhibitory RNA bound to AID. AID catalyzes dC --> dU deamination activity most avidly on double-stranded DNA substrates containing a small transcription-like single-stranded DNA bubble, suggesting a targeting mechanism for this enigmatic enzyme during somatic hypermutation." @default.
• W2036806870 created "2016-06-24" @default.
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• W2036806870 date "2003-03-21" @default.
• W2036806870 modified "2023-10-14" @default.
• W2036806870 title "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase" @default.
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• W2036806870 doi "https://doi.org/10.1073/pnas.0730835100" @default.
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