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- W2036844450 abstract "Abstract A synthetic analogue of methionine enkephalin FK 33–824 was given intravenously to male controls and to male subjects with a history of addiction to heroin lasting 1–4 years. FK 33–824 induced in heroin addicts pituitary responses which were qualitatively and quantitatively comparable to those evoked in healthy subjects, viz. a rise in plasma growth-hormone and prolactin, a lowering in plasma luteinizing hormone and no effect on follicle stimulating hormone. A different behavior was present only for thyrotropin, in that the small rise in plasma titers evident in the healthy subjects after FK 33–824 was lacking in the heroin-addicts. In the latter no significant hormone changes were induced by a placebo. These data indicate that no tolerance is manifested to the neuroendocrine effects of FK-33824 in heroin-addicts. Since FK 33–824 and heroin seem to act in the central nervous system as typical morphine-like substances, it appears that receptors mediating the neuroendocrine effects of opiates are pharmacologically distinct from those mediating behavioral effects." @default.
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- W2036844450 date "1981-08-01" @default.
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- W2036844450 title "Lack of tolerance in heroin-addicts to the neuroendocrine effects of an enkephalin analogue" @default.
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- W2036844450 doi "https://doi.org/10.1016/0024-3205(81)90216-2" @default.
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