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- W2036851370 abstract "BackgroundPathogenesis of chronic obstructive lung disease (COPD) includes primary inflammatory events, multiple vascular reactions, remodeling of bronchial and vascular walls.ObjectiveThe aim of present single-center study was to assess relations between angiotensin-converting enzyme (ACE) gene and prevalence of clinical symptoms characteristic to COPD.MethodsThe study involved sixty-three male patients with COPD (44–86 years old, a mean of 60.4 years). COPD diagnostics was performed according to common criteria, including evaluation of systolic pressure in pulmonary artery (SPPA) and endothelial disfunction (ED). Genotyping of ACE I/D was performed by means of gene-specific PCR.Results1. Allele distribution of studied gene alleles among COPD patients did not differ from control age-matched group. 2. Detectable endothelial dysfunction in COPD patients was shown to correlate with high-producer D allele of ACE gene, at an odds ratio of 6.632 (CI = 1.67–26.31; chi2 = 8.39, p = 0.004). Moreover, detectable ED correlated with numbers of COPD exacerbations per year.ConclusionsThese findings suggest possible association of the functional ACE D allele with altered vascular responses that may modulate development of distinct COPD symptoms. The results are obtained in a limited clinical cohort, and deserve repeated trials in other groups of COPD patients." @default.
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- W2036851370 date "2013-08-01" @default.
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- W2036851370 title "Common intronic D variant of ACE gene is associated with endothelial dysfunction in COPD" @default.
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- W2036851370 doi "https://doi.org/10.1016/j.rmed.2012.12.025" @default.
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