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• W2036866353 abstract "Cervical cancer constitutes a major health problem world-wide. Each year, there are approximately 465 000 new cases and in excess of 200 000 deaths from this disease [1]. The burden is most pronounced in the developing countries, where it accounts for about 30% of all female cancers. Although much effort has been applied to the early detection of cervical cancer by exfoliative cytology and the provision of conservative modalities of treatment for pre-invasive lesions, study of the molecular mechanisms of cervical carcinogenesis has only recently become an intense field of research. The epidemiological pattern of cervical cancer strongly points to a sexually transmitted infectious agent as being aetiologically important. As early as 1842, Rigoni Stern [2] found that, compared with breast cancer, cervical cancer was 18 times more common amongst married than unmarried women in Verona. Modern epidemiological studies have shown low cervical cancer rates among Catholic nuns [3], while higher rates are found in women marrying at younger ages [4,5]. The latter is related more specifically to two aspects of sexual behaviour, namely the number of sexual partners and age at initiation of intercourse [6,7]. The risk associated with 10 or more partners is nearly three times higher than that associated with one or no partners [8,9]. Women having their first sexual experiences before age 16 have about twice the risk compared with women who initiated sexual intercourse after the age of 20 years; this may reflect the increase susceptibility of the 'younger' cervix to carcinogenic insult [10,11]. Based on several epidemiological, clinical and molecular biological data, there is now compelling evidence that the infectious agent with a causal relationship to cervical intraepithelial neoplasia (CIN) and cancer is the human papillomavirus (HPV) [12]. Despite this, the majority of women infected with" @default.
• W2036866353 created "2016-06-24" @default.
• W2036866353 creator A5009400324 @default.
• W2036866353 creator A5059799734 @default.
• W2036866353 date "1997-01-01" @default.
• W2036866353 modified "2023-10-16" @default.
• W2036866353 title "The roles of the human major histocompatibility complex and human papillomavirus infection in cervical intraepithelial neoplasia and cervical cancer" @default.
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• W2036866353 doi "https://doi.org/10.1016/s0936-6555(97)80051-9" @default.
• W2036866353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9039807" @default.
• W2036866353 hasPublicationYear "1997" @default.
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