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• W2036866940 startingPage "45" @default.
• W2036866940 abstract "Working memory dysfunction is considered to be fundamental to the cognitive and clinical features evident in schizophrenia. Functional neuroimaging studies have begun to elucidate the neurobiological basis of such deficits, however, interpretation of these studies may be confounded by performance impairment, when the cognitive load exceeds the limited response capacity of patients with schizophrenia. In this study, patients were pre-selected on the basis of intact performance on a relatively low-load verbal working memory task, in order to mitigate against performance confounds. Subjects included 20 right-handed male subjects with chronic schizophrenia, and 20 right-handed, age-matched, male healthy controls, without personal or familial psychiatric history. All subjects underwent fMRI scanning whilst performing a verbal n-back task. There were no significant between-group differences in target identification; the patient group showed a significantly increased mean response latency. Both groups demonstrated robust fronto-parietal activation. In the control subjects, the power of functional response was positively correlated with reaction time in bilateral posterior parietal cortex, however, this coupling of behavioural performance and cerebral response was not evident in the patients. This deficit, apparent within the performance capacity of the patients, may represent a fundamental abnormality in schizophrenia, and may compromise performance at higher cognitive loads." @default.
• W2036866940 created "2016-06-24" @default.
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• W2036866940 date "2002-01-01" @default.
• W2036866940 modified "2023-10-18" @default.
• W2036866940 title "De-coupling of cognitive performance and cerebral functional response during working memory in schizophrenia." @default.
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• W2036866940 doi "https://doi.org/10.1016/s0920-9964(01)00154-2" @default.
• W2036866940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728837" @default.
• W2036866940 hasPublicationYear "2002" @default.
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