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• W2036882711 abstract "Hemodialysis results in the exposure of patient blood to anticoagulation—usually with heparin—and to contact with the dialyzer artificial surfaces. Either can result in the patient developing one or more untoward symptoms or signs termed “acute systemic reactions” (or “anaphylactoid”) reactions, due to at least two distinct mechanisms [ [1] Warkentin T.E. Greinacher A. Heparin-induced anaphylactic and anaphylactoid reactions: two distinct but overlapping syndromes. Expert Opin Drug Saf. 2009; 8: 129-144 Crossref PubMed Scopus (75) Google Scholar ]. One mechanism is immune heparin-induced thrombocytopenia (HIT); here, in vivo platelet activation occurs due to the consequences of heparin-dependent platelet-activating antibodies that recognize complexes of platelet factor 4 (PF4) bound to heparin. Through poorly-defined mechanisms, abrupt HIT antibody-induced platelet activation upon heparin bolus administration can result in a variety of clinical adverse effects [ [2] Warkentin T.E. Clinical picture of heparin-induced thrombocytopenia. in: Warkentin T.E. Greinacher A. Heparin-induced thrombocytopenia. 4th edition. Informa Healthcare USA, Inc., New York2007: 21-66 Crossref Google Scholar ], including fever, chills [ 3 Hillis C. Warkentin T.E. Taha K. Eikelboom J.W. Chills and limb pain following administration of low-molecular-weight heparin for treatment of acute venous thromboembolism. Am J Hematol. 2011; 86: 603-606 Crossref PubMed Scopus (9) Google Scholar , 4 Ling E. Warkentin T.E. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology. 1998; 89: 1567-1569 Crossref PubMed Scopus (46) Google Scholar ], flushing, tachycardia, blood pressure changes, dyspnea [ 4 Ling E. Warkentin T.E. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology. 1998; 89: 1567-1569 Crossref PubMed Scopus (46) Google Scholar , 5 Hewitt R.L. Akers D.L. Leissinger C.A. Gill J.I. Aster R.H. Concurrence of anaphylaxis and acute heparin-induced thrombocytopenia in a patient with heparin-induced antibodies. J Vasc Surg. 1998; 28: 561-565 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar ], unusual neurologic sequelae (transient global amnesia) [ [6] Warkentin T.E. Hirte H.W. Anderson D.R. Wilson W.E.C. O'Connell G.J. Lo R.C. Transient global amnesia associated with acute heparin-induced thrombocytopenia. Am J Med. 1994; 97: 489-491 Abstract Full Text PDF PubMed Scopus (60) Google Scholar ], and sometimes even pulmonary or cardiac arrest [ 1 Warkentin T.E. Greinacher A. Heparin-induced anaphylactic and anaphylactoid reactions: two distinct but overlapping syndromes. Expert Opin Drug Saf. 2009; 8: 129-144 Crossref PubMed Scopus (75) Google Scholar , 7 Ansell J.E. Clark Jr., W.P. Compton C.C. Fatal reactions associated with intravenous heparin [letter]. Drug Intell Clin Pharm. 1986; 20: 74-75 PubMed Google Scholar , 8 Mims M.P. Manian P. Rice L. Acute cardiorespiratory collapse from heparin: a consequence of heparin-induced thrombocytopenia. Eur J Haematol. 2004; 72: 366-369 Crossref PubMed Scopus (25) Google Scholar ]. Such HIT-associated acute systemic reactions differ from the usual prothrombotic effects of HIT, such as venous and arterial thrombosis (although some patients may suffer from both HIT-associated thrombosis and HIT-associated acute systemic reactions [ 4 Ling E. Warkentin T.E. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology. 1998; 89: 1567-1569 Crossref PubMed Scopus (46) Google Scholar , 5 Hewitt R.L. Akers D.L. Leissinger C.A. Gill J.I. Aster R.H. Concurrence of anaphylaxis and acute heparin-induced thrombocytopenia in a patient with heparin-induced antibodies. J Vasc Surg. 1998; 28: 561-565 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar , 6 Warkentin T.E. Hirte H.W. Anderson D.R. Wilson W.E.C. O'Connell G.J. Lo R.C. Transient global amnesia associated with acute heparin-induced thrombocytopenia. Am J Med. 1994; 97: 489-491 Abstract Full Text PDF PubMed Scopus (60) Google Scholar ])." @default.
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• W2036882711 title "Hemodialysis-Associated Acute Systemic Reactions and Heparin-Induced Thrombocytopenia" @default.
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