FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036886710> ?p ?o ?g. }

• W2036886710 endingPage "504" @default.
• W2036886710 startingPage "497" @default.
• W2036886710 abstract "Tyr83 in endothelial nitric oxide synthase (eNOS) has been identified previously as a site of Src kinase–mediated phosphorylation of eNOS in bovine aortic endothelial cells (BAECs) that is phosphorylated in response to oxidant stress. In the present study, we have used a phospho-specific antibody to show that Tyr83 in eNOS is also phosphorylated in both BAECs and intact blood vessel segments in response to treatment with a variety of different eNOS-activating agonists, including thapsigargin, vascular endothelial growth factor, bradykinin, ATP, sphingosine-1-phosphate, estrogen, angiopoietin, and acetylcholine. Agonist stimulation of eNOS Tyr83 phosphorylation as well as agonist stimulation of endothelial NO release in BAECs is blocked by Src kinase inhibition by either 4-amino-5-(4-chlorophenyl)-7-( t -butyl) pyrazolo [3,4-d] pyrimidine (PP2) or by dominant negative Src. Mutation of Tyr83 to a nonphosphorylatable Phe blocks agonist stimulation of NO release from eNOS-reconstituted eNOS knockdown endothelial cells. Mutation of Tyr83 also attenuates agonist-induced relaxation of eNOS-reconstituted aortic rings from eNOS knockout mice. Phosphorylation of eNOS at Tyr83 thus appears to be a common covalent modification that is induced, not only by oxidant stress but also by other physiologically relevant extracellular signals known to be important in regulation of eNOS activity in vivo. Moreover, our results demonstrate an important role for Src-mediated phosphorylation of eNOS at Tyr83 in agonist stimulation of eNOS activation and vascular relaxation." @default.
• W2036886710 created "2016-06-24" @default.
• W2036886710 creator A5006211588 @default.
• W2036886710 creator A5023006263 @default.
• W2036886710 creator A5052441498 @default.
• W2036886710 creator A5060657469 @default.
• W2036886710 creator A5067804076 @default.
• W2036886710 creator A5075774578 @default.
• W2036886710 date "2008-02-29" @default.
• W2036886710 modified "2023-09-29" @default.
• W2036886710 title "Agonist-Stimulated Endothelial Nitric Oxide Synthase Activation and Vascular Relaxation" @default.
• W2036886710 cites W1607892649 @default.
• W2036886710 cites W1678800844 @default.
• W2036886710 cites W1971222830 @default.
• W2036886710 cites W1976999762 @default.
• W2036886710 cites W1980319073 @default.
• W2036886710 cites W1994768696 @default.
• W2036886710 cites W2024185487 @default.
• W2036886710 cites W2024394653 @default.
• W2036886710 cites W2031707926 @default.
• W2036886710 cites W2038307719 @default.
• W2036886710 cites W2047770461 @default.
• W2036886710 cites W2054150424 @default.
• W2036886710 cites W2057257230 @default.
• W2036886710 cites W2090895449 @default.
• W2036886710 cites W2091193879 @default.
• W2036886710 cites W2091499945 @default.
• W2036886710 cites W2118780544 @default.
• W2036886710 cites W2119043221 @default.
• W2036886710 cites W2132734354 @default.
• W2036886710 cites W2144179854 @default.
• W2036886710 cites W2166468339 @default.
• W2036886710 cites W2169633992 @default.
• W2036886710 cites W4253422011 @default.
• W2036886710 doi "https://doi.org/10.1161/circresaha.107.162933" @default.
• W2036886710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18096817" @default.
• W2036886710 hasPublicationYear "2008" @default.
• W2036886710 type Work @default.
• W2036886710 sameAs 2036886710 @default.
• W2036886710 citedByCount "60" @default.
• W2036886710 countsByYear W20368867102012 @default.
• W2036886710 countsByYear W20368867102013 @default.
• W2036886710 countsByYear W20368867102014 @default.
• W2036886710 countsByYear W20368867102015 @default.
• W2036886710 countsByYear W20368867102016 @default.
• W2036886710 countsByYear W20368867102017 @default.
• W2036886710 countsByYear W20368867102018 @default.
• W2036886710 countsByYear W20368867102019 @default.
• W2036886710 countsByYear W20368867102020 @default.
• W2036886710 countsByYear W20368867102021 @default.
• W2036886710 countsByYear W20368867102022 @default.
• W2036886710 countsByYear W20368867102023 @default.
• W2036886710 crossrefType "journal-article" @default.
• W2036886710 hasAuthorship W2036886710A5006211588 @default.
• W2036886710 hasAuthorship W2036886710A5023006263 @default.
• W2036886710 hasAuthorship W2036886710A5052441498 @default.
• W2036886710 hasAuthorship W2036886710A5060657469 @default.
• W2036886710 hasAuthorship W2036886710A5067804076 @default.
• W2036886710 hasAuthorship W2036886710A5075774578 @default.
• W2036886710 hasBestOaLocation W20368867101 @default.
• W2036886710 hasConcept C11960822 @default.
• W2036886710 hasConcept C120770815 @default.
• W2036886710 hasConcept C126322002 @default.
• W2036886710 hasConcept C134018914 @default.
• W2036886710 hasConcept C170493617 @default.
• W2036886710 hasConcept C185592680 @default.
• W2036886710 hasConcept C24998067 @default.
• W2036886710 hasConcept C2776992346 @default.
• W2036886710 hasConcept C2777622882 @default.
• W2036886710 hasConcept C2778326061 @default.
• W2036886710 hasConcept C2778938600 @default.
• W2036886710 hasConcept C2908688039 @default.
• W2036886710 hasConcept C519581460 @default.
• W2036886710 hasConcept C55493867 @default.
• W2036886710 hasConcept C71924100 @default.
• W2036886710 hasConcept C86803240 @default.
• W2036886710 hasConcept C95444343 @default.
• W2036886710 hasConceptScore W2036886710C11960822 @default.
• W2036886710 hasConceptScore W2036886710C120770815 @default.
• W2036886710 hasConceptScore W2036886710C126322002 @default.
• W2036886710 hasConceptScore W2036886710C134018914 @default.
• W2036886710 hasConceptScore W2036886710C170493617 @default.
• W2036886710 hasConceptScore W2036886710C185592680 @default.
• W2036886710 hasConceptScore W2036886710C24998067 @default.
• W2036886710 hasConceptScore W2036886710C2776992346 @default.
• W2036886710 hasConceptScore W2036886710C2777622882 @default.
• W2036886710 hasConceptScore W2036886710C2778326061 @default.
• W2036886710 hasConceptScore W2036886710C2778938600 @default.
• W2036886710 hasConceptScore W2036886710C2908688039 @default.
• W2036886710 hasConceptScore W2036886710C519581460 @default.
• W2036886710 hasConceptScore W2036886710C55493867 @default.
• W2036886710 hasConceptScore W2036886710C71924100 @default.
• W2036886710 hasConceptScore W2036886710C86803240 @default.
• W2036886710 hasConceptScore W2036886710C95444343 @default.
• W2036886710 hasIssue "4" @default.
• W2036886710 hasLocation W20368867101 @default.
• W2036886710 hasLocation W20368867102 @default.
• W2036886710 hasOpenAccess W2036886710 @default.

• next