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- W2036888911 abstract "Thorough evaluation of a screening test requires conducting a series of studies to ascertain its ability to detect accurately disease, as well as its benefits and costs. In this article, I review the steps involved in evaluating a screening test, using the case of prostate-specific antigen (PSA) screening for prostate cancer as a case study. I discuss designs for quantifying the diagnostic properties of a screening test and compare several different studies that have produced quite different estimates of the diagnostic accuracy of PSA screening. I also review methods that may be used to combine other markers or tests with PSA to improve test accuracy. Determining the benefits of a screening test is complex, particularly when information from randomized trials is lacking. I review several observational studies of PSA benefit and discuss the use of computer models for inferring the impact of screening from trends in population mortality." @default.
- W2036888911 created "2016-06-24" @default.
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- W2036888911 date "2008-05-01" @default.
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- W2036888911 title "Statistical issues in the evaluation of screening and early detection modalities" @default.
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- W2036888911 doi "https://doi.org/10.1016/j.urolonc.2006.11.008" @default.
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