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- W2036888975 abstract "For the first time, the adenylyl cyclase system (ACS) sensitive to biogenic amines in the mollusk Anodonta cygnea ganglions was revealed and characterized. Serotonin and isoproterenol stimulated AC activity and GTP-binding activity of heterotrimeric G-proteins. The AC-stimulating action of serotonin and isoproterenol was blocked by cyproheptadine and adrenergic antagonists, respectively. Using synthetic C-terminal peptides of G-protein alpha-subunit, it was shown that the biogenic amines realized their action on the ACS through different G-protein types: serotonin and isoproterenol activate G(s)-protein, while adrenaline preferably activates G(i)-protein." @default.
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- W2036888975 date "2005-04-01" @default.
- W2036888975 modified "2023-09-23" @default.
- W2036888975 title "Sensitivity of Adenylyl Cyclase Signaling System of the MolluskAnodonta cygneaGanglions to Serotonin and Adrenergic Agonists" @default.
- W2036888975 doi "https://doi.org/10.1196/annals.1327.092" @default.
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