Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036918018> ?p ?o ?g. }
- W2036918018 endingPage "663" @default.
- W2036918018 startingPage "649" @default.
- W2036918018 abstract "It has been widely accepted that vascular hypoperfusion induces oxidative stress and the outcome of this misbalance is brain energy failure. This abnormality leads to neuronal death which manifests as cognitive impairment and the development of brain pathology as in Alzheimer's disease (AD). It has been demonstrated that the AD brain is characterized by impairments in energy metabolism. We theorize that hypoperfusion induced mitochondrial failure plays a key role in the generation of reactive oxygen species, resulting in oxidative damage to brain cellular compartments, especially in the vascular endothelium and in selective population of neurons with high metabolic activity in the AD brain. All of these abnormalities have been found to occur before classic AD pathology inducing neuronal degeneration and amyloid deposition during the progression of AD. Therefore, expanding investigations into both the mechanisms behind amyloid beta (Abeta) deposition and the possible accelerating effects of environmental factors such as chronic hypoxia/reperfusion may open a new avenue for effective treatments of AD. Future studies examining the importance of mitochondrial pathobiology in brain cellular compartments provide insight not only into the better understanding of the neurodegenerative and/or cerebrovascular disease but also provide targets for treating these conditions." @default.
- W2036918018 created "2016-06-24" @default.
- W2036918018 creator A5021420538 @default.
- W2036918018 creator A5072415195 @default.
- W2036918018 creator A5075477128 @default.
- W2036918018 creator A5091482675 @default.
- W2036918018 date "2004-09-01" @default.
- W2036918018 modified "2023-10-12" @default.
- W2036918018 title "Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease" @default.
- W2036918018 cites W119165056 @default.
- W2036918018 cites W1228775382 @default.
- W2036918018 cites W1430026677 @default.
- W2036918018 cites W145905393 @default.
- W2036918018 cites W1490305500 @default.
- W2036918018 cites W1493502680 @default.
- W2036918018 cites W1542215809 @default.
- W2036918018 cites W1544480566 @default.
- W2036918018 cites W1549308915 @default.
- W2036918018 cites W1610854935 @default.
- W2036918018 cites W1643525023 @default.
- W2036918018 cites W1662308449 @default.
- W2036918018 cites W1771725737 @default.
- W2036918018 cites W1896970469 @default.
- W2036918018 cites W1940197145 @default.
- W2036918018 cites W1963860625 @default.
- W2036918018 cites W1972863264 @default.
- W2036918018 cites W1974297683 @default.
- W2036918018 cites W1976541189 @default.
- W2036918018 cites W1977232394 @default.
- W2036918018 cites W1978073725 @default.
- W2036918018 cites W1979243823 @default.
- W2036918018 cites W1981779207 @default.
- W2036918018 cites W1983789627 @default.
- W2036918018 cites W1984964878 @default.
- W2036918018 cites W1986950646 @default.
- W2036918018 cites W1996295607 @default.
- W2036918018 cites W1996303943 @default.
- W2036918018 cites W2002669267 @default.
- W2036918018 cites W2002957102 @default.
- W2036918018 cites W2003617059 @default.
- W2036918018 cites W2004526436 @default.
- W2036918018 cites W2010251102 @default.
- W2036918018 cites W2010754688 @default.
- W2036918018 cites W2013158197 @default.
- W2036918018 cites W2015148186 @default.
- W2036918018 cites W2016293448 @default.
- W2036918018 cites W2018098602 @default.
- W2036918018 cites W2020951538 @default.
- W2036918018 cites W2021128386 @default.
- W2036918018 cites W2024022041 @default.
- W2036918018 cites W2027189256 @default.
- W2036918018 cites W2028148985 @default.
- W2036918018 cites W2031288523 @default.
- W2036918018 cites W2031738386 @default.
- W2036918018 cites W2032350023 @default.
- W2036918018 cites W2035558636 @default.
- W2036918018 cites W2037500564 @default.
- W2036918018 cites W2037542399 @default.
- W2036918018 cites W2038785443 @default.
- W2036918018 cites W2044494908 @default.
- W2036918018 cites W2048193733 @default.
- W2036918018 cites W2048532208 @default.
- W2036918018 cites W2049132241 @default.
- W2036918018 cites W2049192526 @default.
- W2036918018 cites W2049524099 @default.
- W2036918018 cites W2053756526 @default.
- W2036918018 cites W2056293291 @default.
- W2036918018 cites W2061500679 @default.
- W2036918018 cites W2065012668 @default.
- W2036918018 cites W2069787626 @default.
- W2036918018 cites W2071457139 @default.
- W2036918018 cites W2072519644 @default.
- W2036918018 cites W2075274199 @default.
- W2036918018 cites W2081331500 @default.
- W2036918018 cites W2085974525 @default.
- W2036918018 cites W2088547578 @default.
- W2036918018 cites W2092146469 @default.
- W2036918018 cites W2092690041 @default.
- W2036918018 cites W2095100741 @default.
- W2036918018 cites W2095146312 @default.
- W2036918018 cites W2099040516 @default.
- W2036918018 cites W2106192181 @default.
- W2036918018 cites W2113007696 @default.
- W2036918018 cites W2124726981 @default.
- W2036918018 cites W2130087615 @default.
- W2036918018 cites W2130753450 @default.
- W2036918018 cites W2140075873 @default.
- W2036918018 cites W2140298351 @default.
- W2036918018 cites W2143444048 @default.
- W2036918018 cites W2165427528 @default.
- W2036918018 cites W2165773859 @default.
- W2036918018 cites W2171051145 @default.
- W2036918018 cites W2182392789 @default.
- W2036918018 cites W2184012549 @default.
- W2036918018 cites W2219607055 @default.
- W2036918018 cites W2223217290 @default.
- W2036918018 cites W2394636349 @default.
- W2036918018 cites W2416596544 @default.