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• W2036936909 abstract "Abstract Broad Complex (BRC) is a highly conserved, ecdysone‐pathway gene essential for metamorphosis in Drosophila melanogaster , and possibly all holometabolous insects. Alternative splicing among duplicated exons produces several BRC isoforms, each with one zinc‐finger DNA‐binding domain (Z1, Z2, Z3, or Z4), highly expressed at the onset of metamorphosis. BRC‐Z1, BRC‐Z2, and BRC‐Z3 represent distinct genetic functions ( BRC complementation groups rbp, br , and 2Bc , respectively) and are required at discrete stages spanning final‐instar larva through very young pupa. We showed previously that morphogenetic movements necessary for adult CNS maturation require BRC‐Z1, ‐Z2, and ‐Z3, but not at the same time: BRC‐Z1 is required in the mid‐prepupa, BRC‐Z2 and ‐Z3 are required earlier, at the larval‐prepupal transition. To explore how BRC isoforms controlling the same morphogenesis events do so at different times, we examined their central nervous system (CNS) expression patterns during the ≈16 hours bracketing the hormone‐regulated start of metamorphosis. Each isoform had a unique pattern, with BRC‐Z3 being the most distinctive. There was some colocalization of isoform pairs, but no three‐way overlap of BRC‐Z1, ‐Z2, and ‐Z3. Instead, their most prominent expression was in glia (BRC‐Z1), neuroblasts (BRC‐Z2), or neurons (BRC‐Z3). Despite sequence similarity to BRC‐Z1, BRC‐Z4 was expressed in a unique subset of neurons. These data suggest a switch in BRC isoform choice, from BRC‐Z2 in proliferating cells to BRC‐Z1, BRC‐Z3, or BRC‐Z4 in differentiating cells. Together with isoform‐selective temporal requirements and phenotype considerations, this cell‐type‐selective expression suggests a model of BRC‐dependent CNS morphogenesis resulting from intercellular interactions, culminating in BRC‐Z1‐controlled, glia‐mediated CNS movements in late prepupa. J. Comp. Neurol. 517:15–36, 2009. © 2009 Wiley‐Liss, Inc." @default.
• W2036936909 created "2016-06-24" @default.
• W2036936909 creator A5011637469 @default.
• W2036936909 creator A5048675565 @default.
• W2036936909 date "2009-08-26" @default.
• W2036936909 modified "2023-10-12" @default.
• W2036936909 title "Broad complex isoforms have unique distributions during central nervous system metamorphosis in<i>Drosophila melanogaster</i>" @default.
• W2036936909 cites W1514943426 @default.
• W2036936909 cites W1519104467 @default.
• W2036936909 cites W1537800028 @default.
• W2036936909 cites W1920119772 @default.
• W2036936909 cites W1944499597 @default.
• W2036936909 cites W1963436838 @default.
• W2036936909 cites W1964445267 @default.
• W2036936909 cites W1968969383 @default.
• W2036936909 cites W1971101040 @default.
• W2036936909 cites W1971311303 @default.
• W2036936909 cites W1973684479 @default.
• W2036936909 cites W1980454091 @default.
• W2036936909 cites W1984085917 @default.
• W2036936909 cites W1989344944 @default.
• W2036936909 cites W1989575185 @default.
• W2036936909 cites W1993182457 @default.
• W2036936909 cites W1993627985 @default.
• W2036936909 cites W1996432459 @default.
• W2036936909 cites W1998942607 @default.
• W2036936909 cites W2000117107 @default.
• W2036936909 cites W2000517171 @default.
• W2036936909 cites W2000594976 @default.
• W2036936909 cites W2005102796 @default.
• W2036936909 cites W2008399291 @default.
• W2036936909 cites W2008904865 @default.
• W2036936909 cites W2009471336 @default.
• W2036936909 cites W2009647598 @default.
• W2036936909 cites W2013319978 @default.
• W2036936909 cites W2013790912 @default.
• W2036936909 cites W2017439745 @default.
• W2036936909 cites W2018759259 @default.
• W2036936909 cites W2030233815 @default.
• W2036936909 cites W2035288422 @default.
• W2036936909 cites W2036437741 @default.
• W2036936909 cites W2042317651 @default.
• W2036936909 cites W2044278174 @default.
• W2036936909 cites W2045649095 @default.
• W2036936909 cites W2046209045 @default.
• W2036936909 cites W2046218009 @default.
• W2036936909 cites W2046238809 @default.
• W2036936909 cites W2046351375 @default.
• W2036936909 cites W2046462248 @default.
• W2036936909 cites W2047257157 @default.
• W2036936909 cites W2050847788 @default.
• W2036936909 cites W2051660611 @default.
• W2036936909 cites W2053050328 @default.
• W2036936909 cites W2053283145 @default.
• W2036936909 cites W2057184191 @default.
• W2036936909 cites W2058235418 @default.
• W2036936909 cites W2058830778 @default.
• W2036936909 cites W2067975978 @default.
• W2036936909 cites W2068423407 @default.
• W2036936909 cites W2069012550 @default.
• W2036936909 cites W2071453677 @default.
• W2036936909 cites W2071977571 @default.
• W2036936909 cites W2072038233 @default.
• W2036936909 cites W2075754851 @default.
• W2036936909 cites W2077479555 @default.
• W2036936909 cites W2082969720 @default.
• W2036936909 cites W2083206596 @default.
• W2036936909 cites W2092039430 @default.
• W2036936909 cites W2096059852 @default.
• W2036936909 cites W2100876371 @default.
• W2036936909 cites W2101103652 @default.
• W2036936909 cites W2103116478 @default.
• W2036936909 cites W2103239365 @default.
• W2036936909 cites W2104845360 @default.
• W2036936909 cites W2105581244 @default.
• W2036936909 cites W2106061374 @default.
• W2036936909 cites W2108871140 @default.
• W2036936909 cites W2110983797 @default.
• W2036936909 cites W2127170253 @default.
• W2036936909 cites W2130409695 @default.
• W2036936909 cites W2131804282 @default.
• W2036936909 cites W2134801690 @default.
• W2036936909 cites W2136838504 @default.
• W2036936909 cites W2138505000 @default.
• W2036936909 cites W2141539159 @default.
• W2036936909 cites W2143311793 @default.
• W2036936909 cites W2149274570 @default.
• W2036936909 cites W2155984905 @default.
• W2036936909 cites W2156101485 @default.
• W2036936909 cites W2162231449 @default.
• W2036936909 cites W2165349943 @default.
• W2036936909 cites W2167194725 @default.
• W2036936909 cites W2171285569 @default.
• W2036936909 cites W2177609029 @default.
• W2036936909 cites W2184627692 @default.
• W2036936909 cites W2186946794 @default.
• W2036936909 cites W219130699 @default.
• W2036936909 cites W2213727528 @default.

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