FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036951036> ?p ?o ?g. }

• W2036951036 endingPage "557" @default.
• W2036951036 startingPage "551" @default.
• W2036951036 abstract "Objectives:Posaconazole is broadly used for antifungal prophylaxis and therapy. Current data suggest a concentration-dependent effect. Unlike other triazoles, cytochrome P450 is not a relevant route of biotransformation for posaconazole but glucuronidation, which might lead to a different spectrum of drug interactions. For benzodiazepines, the major metabolic pathway involves oxidation, but some, including lorazepam and temazepam, undergo conjugation to glucuronic acid.Research design and methods:Since 2006 serum levels of posaconazole are determined regularly in all hospitalized patients with intake of this triazole. Here we investigate posaconazole concentration at steady state in relation to the concomitant medication of benzodiazepines.Results:While similar posaconazole concentrations were determined in samples obtained from patients receiving temazepam when compared to samples without any benzodiazepine, a relevant reduction of posaconazole concentration could be observed in patients with concomitant intake of lorazepam. This difference in posaconazole concentration with or without concomittant intake of lorazepam, was consistently significant for analyses of all samples (median 336 ng/ml vs. 585 ng/ml, p 0.001), for the average concentrations (569 ng/ml vs. 276 ng/ml, p 0.039), and for patients receiving a total daily dose of 800 mg posaconazole (292 ng/ml vs. 537 ng/ml, p 0.003). There was also a similar, but not significant trend for patients with a prophylactic dosage of 200 mg posaconazole three times daily (689 ng/ml vs. 512 ng/ml, p 0.186).Conclusions:In this retrospective study, analyzing blood samples from daily clinical practice of patients in various clinical settings and with different indications for antifungal therapy, concomitant medication of lorazepam was associated with decreased posaconazole concentrations. Therefore, lorazepam but not temazepam might induce posaconazole clearance by glucuronidation." @default.
• W2036951036 created "2016-06-24" @default.
• W2036951036 creator A5001059196 @default.
• W2036951036 creator A5005670000 @default.
• W2036951036 creator A5015512329 @default.
• W2036951036 creator A5016360607 @default.
• W2036951036 creator A5037590928 @default.
• W2036951036 creator A5038222176 @default.
• W2036951036 creator A5056024875 @default.
• W2036951036 creator A5068396635 @default.
• W2036951036 creator A5082330194 @default.
• W2036951036 date "2012-02-28" @default.
• W2036951036 modified "2023-09-26" @default.
• W2036951036 title "Impact of benzodiazepines on posaconazole serum concentrations. A population-based pharmacokinetic study on drug interaction" @default.
• W2036951036 cites W1570303890 @default.
• W2036951036 cites W1736726786 @default.
• W2036951036 cites W1972764254 @default.
• W2036951036 cites W1994904603 @default.
• W2036951036 cites W2001989400 @default.
• W2036951036 cites W2010436911 @default.
• W2036951036 cites W2011947169 @default.
• W2036951036 cites W2015962108 @default.
• W2036951036 cites W2029753965 @default.
• W2036951036 cites W2030566485 @default.
• W2036951036 cites W2030791966 @default.
• W2036951036 cites W2035518733 @default.
• W2036951036 cites W2039018761 @default.
• W2036951036 cites W2047978949 @default.
• W2036951036 cites W2050544826 @default.
• W2036951036 cites W2077615465 @default.
• W2036951036 cites W2080129180 @default.
• W2036951036 cites W2089667194 @default.
• W2036951036 cites W2096598041 @default.
• W2036951036 cites W2098705403 @default.
• W2036951036 cites W2106243271 @default.
• W2036951036 cites W2110997670 @default.
• W2036951036 cites W2122438818 @default.
• W2036951036 cites W2123114992 @default.
• W2036951036 cites W2123859227 @default.
• W2036951036 cites W2127495700 @default.
• W2036951036 cites W2134774528 @default.
• W2036951036 cites W2136344681 @default.
• W2036951036 cites W2150844178 @default.
• W2036951036 cites W2154955932 @default.
• W2036951036 cites W2155149156 @default.
• W2036951036 cites W2157856480 @default.
• W2036951036 cites W2323853581 @default.
• W2036951036 cites W2332034438 @default.
• W2036951036 doi "https://doi.org/10.1185/03007995.2012.664123" @default.
• W2036951036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22303909" @default.
• W2036951036 hasPublicationYear "2012" @default.
• W2036951036 type Work @default.
• W2036951036 sameAs 2036951036 @default.
• W2036951036 citedByCount "4" @default.
• W2036951036 countsByYear W20369510362012 @default.
• W2036951036 countsByYear W20369510362013 @default.
• W2036951036 countsByYear W20369510362014 @default.
• W2036951036 countsByYear W20369510362015 @default.
• W2036951036 crossrefType "journal-article" @default.
• W2036951036 hasAuthorship W2036951036A5001059196 @default.
• W2036951036 hasAuthorship W2036951036A5005670000 @default.
• W2036951036 hasAuthorship W2036951036A5015512329 @default.
• W2036951036 hasAuthorship W2036951036A5016360607 @default.
• W2036951036 hasAuthorship W2036951036A5037590928 @default.
• W2036951036 hasAuthorship W2036951036A5038222176 @default.
• W2036951036 hasAuthorship W2036951036A5056024875 @default.
• W2036951036 hasAuthorship W2036951036A5068396635 @default.
• W2036951036 hasAuthorship W2036951036A5082330194 @default.
• W2036951036 hasConcept C112705442 @default.
• W2036951036 hasConcept C126322002 @default.
• W2036951036 hasConcept C16005928 @default.
• W2036951036 hasConcept C170493617 @default.
• W2036951036 hasConcept C2777071850 @default.
• W2036951036 hasConcept C2778173252 @default.
• W2036951036 hasConcept C2778566413 @default.
• W2036951036 hasConcept C2779384505 @default.
• W2036951036 hasConcept C2779548794 @default.
• W2036951036 hasConcept C2779706987 @default.
• W2036951036 hasConcept C2780272996 @default.
• W2036951036 hasConcept C2781006864 @default.
• W2036951036 hasConcept C2908647359 @default.
• W2036951036 hasConcept C42219234 @default.
• W2036951036 hasConcept C71924100 @default.
• W2036951036 hasConcept C90924648 @default.
• W2036951036 hasConcept C98274493 @default.
• W2036951036 hasConcept C99454951 @default.
• W2036951036 hasConceptScore W2036951036C112705442 @default.
• W2036951036 hasConceptScore W2036951036C126322002 @default.
• W2036951036 hasConceptScore W2036951036C16005928 @default.
• W2036951036 hasConceptScore W2036951036C170493617 @default.
• W2036951036 hasConceptScore W2036951036C2777071850 @default.
• W2036951036 hasConceptScore W2036951036C2778173252 @default.
• W2036951036 hasConceptScore W2036951036C2778566413 @default.
• W2036951036 hasConceptScore W2036951036C2779384505 @default.
• W2036951036 hasConceptScore W2036951036C2779548794 @default.
• W2036951036 hasConceptScore W2036951036C2779706987 @default.
• W2036951036 hasConceptScore W2036951036C2780272996 @default.
• W2036951036 hasConceptScore W2036951036C2781006864 @default.

• next