FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036951569> ?p ?o ?g. }

• W2036951569 endingPage "102" @default.
• W2036951569 startingPage "98" @default.
• W2036951569 abstract "<h2>Abstract</h2> Although biapenem is used in the treatment of pneumonia, the clinical data on elderly patients are yet insufficient. Therefore, the purpose of this study was evaluating the efficacy and safety of biapenem against pneumonia in the elderly and its pharmacokinetics. The subjects were patients 65 years of age or older with pneumonia. Biapenem (300mg) was administered once to three times per day. For some cases, the drug concentrations in plasma were measured chronologically. The clinical efficacy was evaluated in reference to the improvement in subjective symptoms and objective opinion. The primary outcome was efficacy rate at the end of treatment. Biapenem was effective in 17 of 20 subject cases (85.0 %). Regarding safety, although 4 cases experienced hepatic dysfunction and 1 case had nausea, these effects were not severe in all cases and administration was continued. There was no deterioration of renal function associated with biapenem. In 13 cases in which the trough value of biapenem was measured, there were no unacceptable side effects and the trough values were generally low. It is believed that biapenem (300 mg once to three times a day), even when taken by elderly people, does not accumulate and that the dosage is safe and appropriate. The changes in the predicted concentrations calculated with the pharmacokinetic–pharmacodynamic (PK–PD) software, which is based on previously reported population pharmacokinetic parameters, and those in the measured concentrations approximately matched. It is useful to plan biapenem administration using the PK–PD software when performing antibiotic chemical treatment." @default.
• W2036951569 created "2016-06-24" @default.
• W2036951569 creator A5015445282 @default.
• W2036951569 creator A5033078818 @default.
• W2036951569 creator A5040830060 @default.
• W2036951569 creator A5042674032 @default.
• W2036951569 creator A5047110554 @default.
• W2036951569 creator A5053985948 @default.
• W2036951569 creator A5055004912 @default.
• W2036951569 creator A5055140620 @default.
• W2036951569 creator A5057335737 @default.
• W2036951569 creator A5062944401 @default.
• W2036951569 creator A5065273321 @default.
• W2036951569 creator A5077220855 @default.
• W2036951569 date "2013-01-01" @default.
• W2036951569 modified "2023-10-16" @default.
• W2036951569 title "Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics" @default.
• W2036951569 cites W2010921812 @default.
• W2036951569 cites W2039721590 @default.
• W2036951569 cites W2105664764 @default.
• W2036951569 cites W2320270386 @default.
• W2036951569 cites W2325727884 @default.
• W2036951569 cites W572348853 @default.
• W2036951569 doi "https://doi.org/10.1007/s10156-012-0463-y" @default.
• W2036951569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22926665" @default.
• W2036951569 hasPublicationYear "2013" @default.
• W2036951569 type Work @default.
• W2036951569 sameAs 2036951569 @default.
• W2036951569 citedByCount "14" @default.
• W2036951569 countsByYear W20369515692013 @default.
• W2036951569 countsByYear W20369515692014 @default.
• W2036951569 countsByYear W20369515692015 @default.
• W2036951569 countsByYear W20369515692016 @default.
• W2036951569 countsByYear W20369515692019 @default.
• W2036951569 countsByYear W20369515692020 @default.
• W2036951569 countsByYear W20369515692021 @default.
• W2036951569 countsByYear W20369515692022 @default.
• W2036951569 countsByYear W20369515692023 @default.
• W2036951569 crossrefType "journal-article" @default.
• W2036951569 hasAuthorship W2036951569A5015445282 @default.
• W2036951569 hasAuthorship W2036951569A5033078818 @default.
• W2036951569 hasAuthorship W2036951569A5040830060 @default.
• W2036951569 hasAuthorship W2036951569A5042674032 @default.
• W2036951569 hasAuthorship W2036951569A5047110554 @default.
• W2036951569 hasAuthorship W2036951569A5053985948 @default.
• W2036951569 hasAuthorship W2036951569A5055004912 @default.
• W2036951569 hasAuthorship W2036951569A5055140620 @default.
• W2036951569 hasAuthorship W2036951569A5057335737 @default.
• W2036951569 hasAuthorship W2036951569A5062944401 @default.
• W2036951569 hasAuthorship W2036951569A5065273321 @default.
• W2036951569 hasAuthorship W2036951569A5077220855 @default.
• W2036951569 hasConcept C111113717 @default.
• W2036951569 hasConcept C112705442 @default.
• W2036951569 hasConcept C126322002 @default.
• W2036951569 hasConcept C177713679 @default.
• W2036951569 hasConcept C2777914695 @default.
• W2036951569 hasConcept C2780580376 @default.
• W2036951569 hasConcept C2908647359 @default.
• W2036951569 hasConcept C71924100 @default.
• W2036951569 hasConcept C98274493 @default.
• W2036951569 hasConcept C99454951 @default.
• W2036951569 hasConceptScore W2036951569C111113717 @default.
• W2036951569 hasConceptScore W2036951569C112705442 @default.
• W2036951569 hasConceptScore W2036951569C126322002 @default.
• W2036951569 hasConceptScore W2036951569C177713679 @default.
• W2036951569 hasConceptScore W2036951569C2777914695 @default.
• W2036951569 hasConceptScore W2036951569C2780580376 @default.
• W2036951569 hasConceptScore W2036951569C2908647359 @default.
• W2036951569 hasConceptScore W2036951569C71924100 @default.
• W2036951569 hasConceptScore W2036951569C98274493 @default.
• W2036951569 hasConceptScore W2036951569C99454951 @default.
• W2036951569 hasIssue "1" @default.
• W2036951569 hasLocation W20369515691 @default.
• W2036951569 hasLocation W20369515692 @default.
• W2036951569 hasOpenAccess W2036951569 @default.
• W2036951569 hasPrimaryLocation W20369515691 @default.
• W2036951569 hasRelatedWork W1758514097 @default.
• W2036951569 hasRelatedWork W1850703972 @default.
• W2036951569 hasRelatedWork W1997101420 @default.
• W2036951569 hasRelatedWork W2010116591 @default.
• W2036951569 hasRelatedWork W2090099591 @default.
• W2036951569 hasRelatedWork W2227061539 @default.
• W2036951569 hasRelatedWork W2410816841 @default.
• W2036951569 hasRelatedWork W2477866235 @default.
• W2036951569 hasRelatedWork W2594910449 @default.
• W2036951569 hasRelatedWork W2992709639 @default.
• W2036951569 hasVolume "19" @default.
• W2036951569 isParatext "false" @default.
• W2036951569 isRetracted "false" @default.
• W2036951569 magId "2036951569" @default.
• W2036951569 workType "article" @default.