FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2036962720> ?p ?o ?g. }

• W2036962720 endingPage "512" @default.
• W2036962720 startingPage "481" @default.
• W2036962720 abstract "Daunorubicin has been entrapped into small unilamellar vesicles (50-80 nm dia) composed of a 2:1 mole ratio of highly purified DSPC:cholesterol. In earlier studies, liposomes of this size and composition had been demonstrated to deliver their entrapped contents selectively to a wide range of solid tumors in vivo. Preclinical and initial clinical investigations of these daunorubicin liposomes (DaunoXome) are discussed. In one murine solid tumor model (P1798 lymphosarcoma), a ten-fold increased delivery of entrapped daunorubicin to tumor tissue was observed. Efficacy studies in the same model indicated improved tumor regression and extended life spans that correlated with the observed degree of enhanced tumor drug delivery. In a second tumor model (MA16C mammary adenocarcinoma), a ten-fold enhancement in efficacy again was demonstrated. In terms of median survival times and long term survival rate, DaunoXome dosed at 2 mg/kg (daunorubicin) demonstrated an efficacy comparable to free drug at 20 mg/kg. Clinical pharmacokinetics paralleled findings from animal studies. In humans, DaunoXome produced daunorubicin plasma AUC levels that were more than 35-fold greater than those reported for comparable doses of free drug at 80 mg/m2. Response rates above 50% have been shown for treatment of Kaposi's sarcoma. A low incidence of side effects has been observed and HIV positive patients have been able to continue antiviral therapy during DaunoXome treatments. Cardiotoxicity has not manifested clinically even for patients receiving in excess of 1 gram/m2 cumulative daunorubicin." @default.
• W2036962720 created "2016-06-24" @default.
• W2036962720 creator A5057343469 @default.
• W2036962720 creator A5068210637 @default.
• W2036962720 date "1994-01-01" @default.
• W2036962720 modified "2023-10-12" @default.
• W2036962720 title "Daunoxome® Treatment of Solid Tumors: Preclinical and Clinical Investigations" @default.
• W2036962720 cites W1964306615 @default.
• W2036962720 cites W1966172935 @default.
• W2036962720 cites W1967838912 @default.
• W2036962720 cites W1971226006 @default.
• W2036962720 cites W1983636374 @default.
• W2036962720 cites W1986122526 @default.
• W2036962720 cites W1993652571 @default.
• W2036962720 cites W2010587003 @default.
• W2036962720 cites W2012879110 @default.
• W2036962720 cites W2013942895 @default.
• W2036962720 cites W2014555065 @default.
• W2036962720 cites W2030593484 @default.
• W2036962720 cites W2037128345 @default.
• W2036962720 cites W2037726220 @default.
• W2036962720 cites W2039337881 @default.
• W2036962720 cites W2040245410 @default.
• W2036962720 cites W2047421804 @default.
• W2036962720 cites W206402243 @default.
• W2036962720 cites W2069957599 @default.
• W2036962720 cites W2075281405 @default.
• W2036962720 cites W2076918344 @default.
• W2036962720 cites W2090779887 @default.
• W2036962720 cites W2093442802 @default.
• W2036962720 cites W2106695694 @default.
• W2036962720 cites W2143227453 @default.
• W2036962720 cites W2148952872 @default.
• W2036962720 cites W2149870649 @default.
• W2036962720 cites W2157928019 @default.
• W2036962720 cites W2404891414 @default.
• W2036962720 cites W2408788590 @default.
• W2036962720 cites W2410351897 @default.
• W2036962720 doi "https://doi.org/10.3109/08982109409037058" @default.
• W2036962720 hasPublicationYear "1994" @default.
• W2036962720 type Work @default.
• W2036962720 sameAs 2036962720 @default.
• W2036962720 citedByCount "105" @default.
• W2036962720 countsByYear W20369627202012 @default.
• W2036962720 countsByYear W20369627202013 @default.
• W2036962720 countsByYear W20369627202014 @default.
• W2036962720 countsByYear W20369627202015 @default.
• W2036962720 countsByYear W20369627202016 @default.
• W2036962720 countsByYear W20369627202017 @default.
• W2036962720 countsByYear W20369627202018 @default.
• W2036962720 countsByYear W20369627202019 @default.
• W2036962720 countsByYear W20369627202020 @default.
• W2036962720 countsByYear W20369627202021 @default.
• W2036962720 countsByYear W20369627202022 @default.
• W2036962720 countsByYear W20369627202023 @default.
• W2036962720 crossrefType "journal-article" @default.
• W2036962720 hasAuthorship W2036962720A5057343469 @default.
• W2036962720 hasAuthorship W2036962720A5068210637 @default.
• W2036962720 hasConcept C112705442 @default.
• W2036962720 hasConcept C121608353 @default.
• W2036962720 hasConcept C126322002 @default.
• W2036962720 hasConcept C150903083 @default.
• W2036962720 hasConcept C178790620 @default.
• W2036962720 hasConcept C185154212 @default.
• W2036962720 hasConcept C185592680 @default.
• W2036962720 hasConcept C207001950 @default.
• W2036962720 hasConcept C2776694085 @default.
• W2036962720 hasConcept C2776802502 @default.
• W2036962720 hasConcept C2778233292 @default.
• W2036962720 hasConcept C2779820397 @default.
• W2036962720 hasConcept C2780035454 @default.
• W2036962720 hasConcept C2781021840 @default.
• W2036962720 hasConcept C29730261 @default.
• W2036962720 hasConcept C530470458 @default.
• W2036962720 hasConcept C55493867 @default.
• W2036962720 hasConcept C71924100 @default.
• W2036962720 hasConcept C86803240 @default.
• W2036962720 hasConcept C98274493 @default.
• W2036962720 hasConceptScore W2036962720C112705442 @default.
• W2036962720 hasConceptScore W2036962720C121608353 @default.
• W2036962720 hasConceptScore W2036962720C126322002 @default.
• W2036962720 hasConceptScore W2036962720C150903083 @default.
• W2036962720 hasConceptScore W2036962720C178790620 @default.
• W2036962720 hasConceptScore W2036962720C185154212 @default.
• W2036962720 hasConceptScore W2036962720C185592680 @default.
• W2036962720 hasConceptScore W2036962720C207001950 @default.
• W2036962720 hasConceptScore W2036962720C2776694085 @default.
• W2036962720 hasConceptScore W2036962720C2776802502 @default.
• W2036962720 hasConceptScore W2036962720C2778233292 @default.
• W2036962720 hasConceptScore W2036962720C2779820397 @default.
• W2036962720 hasConceptScore W2036962720C2780035454 @default.
• W2036962720 hasConceptScore W2036962720C2781021840 @default.
• W2036962720 hasConceptScore W2036962720C29730261 @default.
• W2036962720 hasConceptScore W2036962720C530470458 @default.
• W2036962720 hasConceptScore W2036962720C55493867 @default.
• W2036962720 hasConceptScore W2036962720C71924100 @default.
• W2036962720 hasConceptScore W2036962720C86803240 @default.
• W2036962720 hasConceptScore W2036962720C98274493 @default.

• next