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• W2036971698 abstract "Abstract Aim To investigate the influence of E nterococcus faecalis lipoteichoic acid ( LTA ) on the key bone resorption‐regulating proteins, receptor activator of nuclear factor‐κ B ligand ( RANKL ) and osteoprotegerin ( OPG ) in human periodontal ligament fibroblasts ( PDL cells). Methodology Periodontal ligament cells were subjected to various concentrations of LTA . Cell viability was then determined by methyl thiazolyl tetrazolium ( MTT ) assay, whilst the expression levels of RANKL and OPG were investigated by enzyme‐linked immunosorbent assay ( ELISA ) and W estern blotting. The effect of the inhibitors [ IL ‐1 receptor‐associated kinase ( IRAK )‐1/4, p38 mitogen‐activated protein kinase ( MAPK ) (SB203580)] on LTA ‐stimulated RANKL / OPG activation was examined. Cell viability and RANKL / OPG ratio in PDL cells were also analysed by MTT assay and W estern blotting. Data were analysed using one‐way anova or t ‐test at a significance level of P = 0.05. Result Cell viability was reduced significantly in the LTA group in a dose‐dependent fashion ( P < 0.05). In addition, LTA was found to upregulate the protein expression of RANKL , OPG and their relative ratio in PDL cells ( P < 0.05). The optimal concentration of LTA used in PDL cells was determined to be 10 μg mL −1 . Following IRAK 1/4 and p38 MAPK inhibition, LTA ‐stimulated increases of RANKL / OPG ratio were significantly reduced ( P < 0.05). Conclusion Enterococcus faecalis LTA could upregulate the expression of RANKL and OPG at different rates, suggesting a potential role for LTA in the bone resorption process of refractory apical periodontitis through the regulation of RANKL and OPG . In addition, IRAK 1/4 and p38 MAPK signalling involving RANKL / OPG may contribute to inflammatory responses from PDL cells." @default.
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• W2036971698 date "2013-05-25" @default.
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• W2036971698 title "Effects of<i>Enterococcus faecalis</i>lipoteichoic acid on receptor activator of nuclear factor-κB ligand and osteoprotegerin expression in periodontal ligament fibroblasts" @default.
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• W2036971698 doi "https://doi.org/10.1111/iej.12127" @default.
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