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- W2036982788 abstract "Most patients infected with hepatitis C virus (HCV) become chronic carriers. Viruses that efficiently establish persistent infections must have effective ways of evading host defenses. In the case of HCV, little is known about how chronic infections are established or maintained. Besides hepatocytes, several reports suggest that HCV can infect T and B lymphocytes. Since T cells are essential for viral clearance, direct or indirect effects of HCV on T-cell function could influence the outcome of infection. Given that T-cell growth and differentiation require the cytokine interleukin 2 (IL-2), we asked whether HCV might modulate synthesis of IL-2. Portions of the HCV polyprotein were expressed in Jurkat cells under a variety of conditions. We found that the highly conserved HCV core protein, in combination with other stimuli, was able to dramatically activate transcription from the IL-2 promoter. The carboxy-terminal hydrophobic portion of the core protein was required for this activity. Activation was dependent on nuclear factor of activated T cells (NFAT), occurred in cells deficient in the tyrosine kinase p56(lck), and could be blocked by addition of cyclosporin A and by depletion of calcium. These results suggest that the HCV core protein can activate transcription of the IL-2 promoter through the NFAT pathway. This novel activity may have consequences for T-cell development and establishment of persistent infections." @default.
- W2036982788 created "2016-06-24" @default.
- W2036982788 creator A5019683467 @default.
- W2036982788 creator A5043399976 @default.
- W2036982788 date "2001-01-15" @default.
- W2036982788 modified "2023-10-14" @default.
- W2036982788 title "Transcriptional Activation of the Interleukin-2 Promoter by Hepatitis C Virus Core Protein" @default.
- W2036982788 cites W128911665 @default.
- W2036982788 cites W1479877946 @default.
- W2036982788 cites W1557755285 @default.
- W2036982788 cites W1576049371 @default.
- W2036982788 cites W1601157315 @default.
- W2036982788 cites W1644202690 @default.
- W2036982788 cites W1645159332 @default.
- W2036982788 cites W1784997902 @default.
- W2036982788 cites W1842374849 @default.
- W2036982788 cites W1903527561 @default.
- W2036982788 cites W1957867949 @default.
- W2036982788 cites W1963654011 @default.
- W2036982788 cites W1968426124 @default.
- W2036982788 cites W1970842110 @default.
- W2036982788 cites W1971621821 @default.
- W2036982788 cites W1972846278 @default.
- W2036982788 cites W1976844675 @default.
- W2036982788 cites W1979931682 @default.
- W2036982788 cites W1981070246 @default.
- W2036982788 cites W1989781896 @default.
- W2036982788 cites W1991378085 @default.
- W2036982788 cites W1992908452 @default.
- W2036982788 cites W2002971054 @default.
- W2036982788 cites W2003243698 @default.
- W2036982788 cites W2007119568 @default.
- W2036982788 cites W2009597900 @default.
- W2036982788 cites W2013740977 @default.
- W2036982788 cites W2017311565 @default.
- W2036982788 cites W2022741181 @default.
- W2036982788 cites W2026181894 @default.
- W2036982788 cites W2030380453 @default.
- W2036982788 cites W2035562653 @default.
- W2036982788 cites W2037666513 @default.
- W2036982788 cites W2037829048 @default.
- W2036982788 cites W2042038647 @default.
- W2036982788 cites W2045562270 @default.
- W2036982788 cites W2047999732 @default.
- W2036982788 cites W2049144383 @default.
- W2036982788 cites W2051181783 @default.
- W2036982788 cites W2052325775 @default.
- W2036982788 cites W2053132428 @default.
- W2036982788 cites W2059457521 @default.
- W2036982788 cites W2061299331 @default.
- W2036982788 cites W2068211039 @default.
- W2036982788 cites W2070968956 @default.
- W2036982788 cites W2073612053 @default.
- W2036982788 cites W2076338812 @default.
- W2036982788 cites W2078964482 @default.
- W2036982788 cites W2079395665 @default.
- W2036982788 cites W2086776723 @default.
- W2036982788 cites W2087928892 @default.
- W2036982788 cites W2088165891 @default.
- W2036982788 cites W2090973261 @default.
- W2036982788 cites W2091665751 @default.
- W2036982788 cites W2101274136 @default.
- W2036982788 cites W2107566186 @default.
- W2036982788 cites W2108931379 @default.
- W2036982788 cites W2113393768 @default.
- W2036982788 cites W2115074165 @default.
- W2036982788 cites W2122353285 @default.
- W2036982788 cites W2124473841 @default.
- W2036982788 cites W2125353176 @default.
- W2036982788 cites W2134692276 @default.
- W2036982788 cites W2135213970 @default.
- W2036982788 cites W2135932999 @default.
- W2036982788 cites W2137407985 @default.
- W2036982788 cites W2139550372 @default.
- W2036982788 cites W2140707292 @default.
- W2036982788 cites W2141894346 @default.
- W2036982788 cites W2142378209 @default.
- W2036982788 cites W2146942744 @default.
- W2036982788 cites W2158697492 @default.
- W2036982788 cites W2160442447 @default.
- W2036982788 cites W2165674239 @default.
- W2036982788 cites W2166761234 @default.
- W2036982788 cites W2168889062 @default.
- W2036982788 cites W2404064356 @default.
- W2036982788 cites W2414864158 @default.
- W2036982788 cites W2416542523 @default.
- W2036982788 cites W4230449835 @default.
- W2036982788 cites W4232300325 @default.
- W2036982788 cites W4236571285 @default.
- W2036982788 cites W4300681276 @default.
- W2036982788 cites W2021513498 @default.
- W2036982788 doi "https://doi.org/10.1128/jvi.75.2.772-781.2001" @default.
- W2036982788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/113973" @default.
- W2036982788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11134290" @default.
- W2036982788 hasPublicationYear "2001" @default.
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