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- W2036996816 abstract "Phorbol ester TPA has been previously shown to induce a rapid translocation, followed by a progressive decline of protein kinase C activity in MCF-7 cells (J.M. DARBON et al, 1986, Biochem. Biophys. Res. Comm. 137: 1159–1166). We show now a parallel TPA-induced movement of phorbol ester binding sites from the cytosolic to the particulate fraction with no change in the binding affinities for the (3H) PDBu probe (KD⋍2nM). The subcellular redistribution process is followed by a rapid decrease of the phorbol ester binding capacity a the membrane level. The concomitant decline in both phorbol ester binding and protein kinase C activities that we observed during the course of TPA treatment strongly argues for a real down-regulation of the enzyme in phorbol ester-treated MCF-7 cells. The molecular mechanisms of these events and their relations to the inhibition of cell growth remain to be clarified." @default.
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- W2036996816 date "1987-07-01" @default.
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- W2036996816 title "TPA induces subcellular translocation and subsequent down-regulation of both phorbol ester binding and protein kinase C activities in MCF-7 cells" @default.
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- W2036996816 doi "https://doi.org/10.1016/0006-291x(87)90562-6" @default.
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